Basic information

Full name
GINS complex subunit 1
Ensembl
ENSG00000101003.10
Summary
The yeast heterotetrameric GINS complex is made up of Sld5 (GINS4; MIM 610611), Psf1, Psf2 (GINS2; MIM 610609), and Psf3 (GINS3; MIM 610610). The formation of the GINS complex is essential for the initiation of DNA replication in yeast and Xenopus egg extracts (Ueno et al., 2005 [PubMed 16287864]).[supplied by OMIM, Mar 2008]
Annotation
Essential genes

Protein product

  • ENST00000262460.5 Primary ENSP00000262460.4 (0 phosphosite)
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.9e-101-1.4e-17--1.6e-181.9e-346.6e-35-5e-9-
protein8.6e-10-3.9e-12--1.4e-34.5e-19-0.57-2.8e-60.94

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC456789101112log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCOVPDACUCEC17.51818.51919.52020.52121.52222.52323.52424.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC05101520253035400-5-10-15-20-25-30-35-40Pan-cancer0204060801001201401601802002200-20-40-60-80-100-120-140-160-180-200-220proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GINS1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_E2F_TARGETS4.1e-291.2e-8-0.11-4.3e-72.2e-162.2e-16-0.028-0.514.8e-6
HALLMARK_G2M_CHECKPOINT2e-241.4e-8-0.2-6.4e-61.6e-92.2e-16-0.04-0.375.4e-6
KINASE-PSP_CDK29.6e-249.1e-10-0.42-8.0e-62.2e-161.8e-6-0.310.692.4e-5
KINASE-PSP_CDK11.7e-201.3e-60.38-1.7e-53.2e-92.5e-8-0.710.931.9e-5
PERT-PSP_NOCODAZOLE2e-191e-9-0.83-3.8e-35.7e-61.6e-7-0.210.458.9e-7
HALLMARK_MYC_TARGETS_V22.1e-192.5e-3-0.11-7.3e-47.6e-132.2e-16-0.40.733.7e-5
HALLMARK_SPERMATOGENESIS1.6e-164.4e-4-0.41-0.052.2e-162.2e-16--0.910.90.024
HALLMARK_MITOTIC_SPINDLE8.6e-124.6e-6-0.43-3.7e-60.0035.8e-3-0.260.663.2e-4
HALLMARK_DNA_REPAIR1.9e-110.11-9.6e-3-1.2e-31.1e-66.4e-10-0.0330.974.2e-4
HALLMARK_MYC_TARGETS_V13.4e-113.4e-4-6.8e-3-1.9e-34.6e-52.0e-5-0.150.831.7e-6
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GINS1

BRCA0.500.010.40proteinmRNASCNVmethylationCCRCC-0.05-0.040.25proteinmRNASCNVmethylationCOAD0.65proteinmRNASCNVmethylationGBM0.590.080.34proteinmRNASCNVmethylationHNSCC0.620.170.51proteinmRNASCNVmethylationLSCC0.640.260.54proteinmRNASCNVmethylationLUAD0.38proteinmRNASCNVmethylationOV0.35-0.070.31proteinmRNASCNVmethylationPDAC-0.170.070.33proteinmRNASCNVmethylationUCEC0.44-0.090.29proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GINS1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.