Basic information

Full name
glutaredoxin 2
Ensembl
ENSG00000023572.9
Summary
The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]

Protein product

  • ENST00000367439.7 Primary ENSP00000356409.3 (0 phosphosite)
  • ENST00000367440.3
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.1e-15-0.51---0.372e-74e-15-3.2e-7-
protein-1.1e-6--3e-15---7.9e-4-0.81-2.9e-3-0.0190.86

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC55.566.577.588.599.51010.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC1415161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer0510152025300-5-10-15-20-25-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GLRX2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
chromosomal instability2.8e-40.0577.2e-3-0.6-0.240.440.580.197.2e-30.1
DISEASE-PSP_Alzheimer's_disease4.2e-3---2.7e-4-----0.69
Clinical: Tumor_Size_cm4.5e-3-0.36-8.2e-3-0.960.14-0.85-0.0180.73
xcell: Mast cell9.8e-3-0.250.03-0.80.10.19-0.131.7e-30.420.28
PROGENy: JAK-STAT0.014-0.99-0.63-0.470.44-10.560.889.2e-50.086
HALLMARK_G2M_CHECKPOINT0.0270.0550.36--0.78-0.740.0380.72-0.841.5e-3-0.31
HALLMARK_INTERFERON_ALPHA_RESPONSE0.0320.88-0.71-0.40.49-0.860.680.979.6e-40.12
HALLMARK_MYC_TARGETS_V20.0322.8e-30.21--0.0350.585.5e-30.68-0.490.12-0.76
cibersort: Macrophage M00.0340.673.2e-3-0.230.250.350.95-0.39-0.460.22
KINASE-PSP_Chk1/CHEK10.035----0.110.60.530.120.210.390.019
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GLRX2

BRCA0.360.280.49proteinmRNASCNVmethylationCCRCC0.45-0.000.25-0.030.32-0.04proteinmRNASCNVmethylationCOAD0.34proteinmRNASCNVmethylationGBM0.240.020.160.330.160.20proteinmRNASCNVmethylationHNSCC0.03-0.07-0.18-0.010.180.08proteinmRNASCNVmethylationLSCC0.43-0.300.35-0.050.48-0.04proteinmRNASCNVmethylationLUAD0.20-0.020.070.110.360.06proteinmRNASCNVmethylationOV-0.22-0.010.23proteinmRNASCNVmethylationPDAC0.270.030.100.120.36-0.07proteinmRNASCNVmethylationUCEC0.320.090.280.110.490.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GLRX2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.