Basic information
- Full name
- G protein subunit gamma transducin 2
- Ensembl
- ENSG00000167083.7
- Summary
- Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]
Protein product
- ENST00000507680.6 Primary ENSP00000421710.1 (0 phosphosite)
- ENST00000511277.5
- ENST00000300406.6
- ENST00000515635.5
- ENST00000511673.1
- ENST00000503070.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -1.4e-5 | - | 2.9e-25 | - | - | 2.8e-4 | -5.1e-24 | -5.9e-18 | - | -4.7e-3 | - |
protein | -3.4e-8 | - | - | - | - | - | -8.4e-6 | -8.0e-4 | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of GNGT2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
xcell: immune score | 3.7e-15 | - | 0.043 | - | 2.2e-16 | - | 2.3e-5 | 0.21 | - | - | - | |
ESTIMATE: ImmuneScore | 4e-13 | - | 0.027 | - | 1e-8 | - | 1.2e-7 | 0.2 | - | - | - | |
HALLMARK_ALLOGRAFT_REJECTION | 8.9e-13 | - | 0.055 | - | 1.2e-7 | - | 2.7e-8 | 0.13 | - | - | - | |
ESTIMATE: ESTIMATEScore | 2.1e-11 | - | 0.011 | - | 7.9e-8 | - | 4.7e-6 | 0.36 | - | - | - | |
xcell: microenvironment score | 4.4e-11 | - | 0.045 | - | 2.4e-8 | - | 2.8e-5 | 0.16 | - | - | - | |
xcell: Macrophage | 2e-10 | - | 0.043 | - | 6.1e-9 | - | 6.6e-6 | 0.71 | - | - | - | |
HALLMARK_IL6_JAK_STAT3_SIGNALING | 3.5e-10 | - | 0.097 | - | 1.2e-5 | - | 6.9e-9 | 0.47 | - | - | - | |
xcell: Macrophage M1 | 2.4e-9 | - | 0.11 | - | 6.3e-8 | - | 3.9e-6 | 0.74 | - | - | - | |
HALLMARK_COMPLEMENT | 3.1e-9 | - | 0.053 | - | 1.1e-6 | - | 1.4e-7 | -0.82 | - | - | - | |
HALLMARK_INTERFERON_GAMMA_RESPONSE | 3.3e-9 | - | 0.36 | - | 1.1e-3 | - | 6.9e-9 | 0.062 | - | - | - |
Cis-association
Associations between omics data of GNGT2
Trans-association
Associations of the protein abundance of GNGT2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.