Basic information

Full name
G protein subunit gamma transducin 2
Ensembl
ENSG00000167083.7
Summary
Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein is thought to play a crucial role in cone phototransduction. It belongs to the G protein gamma family and localized specifically in cones. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2010]

Protein product

  • ENST00000507680.6 Primary ENSP00000421710.1 (0 phosphosite)
  • ENST00000511277.5
  • ENST00000300406.6
  • ENST00000515635.5
  • ENST00000511673.1
  • ENST00000503070.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.4e-5-2.9e-25--2.8e-4-5.1e-24-5.9e-18--4.7e-3-
protein-3.4e-8------8.4e-6-8.0e-4---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910log2(RSEM+1)tumornormal
Protein expression
CCRCCGBMLSCCLUADUCEC141516171819202122log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC05101520253035400-5-10-15-20-25-30-35-40Pan-cancer0204060801001201401600-20-40-60-80-100-120-140-160proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GNGT2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: immune score3.7e-15-0.043-2.2e-16-2.3e-50.21---
ESTIMATE: ImmuneScore4e-13-0.027-1e-8-1.2e-70.2---
HALLMARK_ALLOGRAFT_REJECTION8.9e-13-0.055-1.2e-7-2.7e-80.13---
ESTIMATE: ESTIMATEScore2.1e-11-0.011-7.9e-8-4.7e-60.36---
xcell: microenvironment score4.4e-11-0.045-2.4e-8-2.8e-50.16---
xcell: Macrophage2e-10-0.043-6.1e-9-6.6e-60.71---
HALLMARK_IL6_JAK_STAT3_SIGNALING3.5e-10-0.097-1.2e-5-6.9e-90.47---
xcell: Macrophage M12.4e-9-0.11-6.3e-8-3.9e-60.74---
HALLMARK_COMPLEMENT3.1e-9-0.053-1.1e-6-1.4e-7-0.82---
HALLMARK_INTERFERON_GAMMA_RESPONSE3.3e-9-0.36-1.1e-3-6.9e-90.062---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GNGT2

BRCA-0.06proteinmRNASCNVmethylationCCRCC0.430.050.11proteinmRNASCNVmethylationCOAD-0.09proteinmRNASCNVmethylationGBM0.710.09-0.01proteinmRNASCNVmethylationHNSCC-0.38proteinmRNASCNVmethylationLSCC0.56-0.22-0.24proteinmRNASCNVmethylationLUAD0.37-0.17-0.05proteinmRNASCNVmethylationOV0.27proteinmRNASCNVmethylationPDAC-0.13proteinmRNASCNVmethylationUCEC0.05proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GNGT2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.