Gene: GPR3

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
G protein-coupled receptor 3
Ensembl
ENSG00000181773.7
Summary
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
Annotation
IDG target Druggable target (Tier T4)

Protein product

  • ENST00000374024.4 Primary ENSP00000363136.3 (0 phosphosite)
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.3e-4-3.9e-5--7.3e-5-0.130.73-0.18-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025300-5-10-15-20-25-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GPR3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: Macrophage M2-----------
cibersort: Eosinophil-----------
xcell: T cell CD4+ memory-----------
xcell: T cell CD4+ effector memory-----------
HALLMARK_HEME_METABOLISM-----------
HALLMARK_PEROXISOME-----------
HALLMARK_KRAS_SIGNALING_DN-----------
PROGENy: Estrogen-----------
PROGENy: NFkB-----------
LMAN1 mutation-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GPR3

BRCA0.24proteinmRNASCNVmethylationCCRCC-0.040.050.08proteinmRNASCNVmethylationCOAD0.35proteinmRNASCNVmethylationGBM-0.000.100.15proteinmRNASCNVmethylationHNSCC-0.00-0.19-0.02proteinmRNASCNVmethylationLSCC-0.050.15-0.16proteinmRNASCNVmethylationLUAD0.070.100.11proteinmRNASCNVmethylationOV0.39proteinmRNASCNVmethylationPDAC-0.030.24-0.03proteinmRNASCNVmethylationUCEC0.06-0.07-0.17proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GPR3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.