Gene: GPX3

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
glutathione peroxidase 3
Ensembl
ENSG00000211445.12
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Annotation
Druggable target (Tier T4)

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.1e-101--2.7e-22---1.2e-20-1.7e-34-2.7e-34--1.2e-5-
protein-6.7e-78--1.4e-30-3.5e-17--4.7e-25-6.7e-33-2.2e-27-3e-81.1e-11-0.29

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC678910111213141516171819log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC232425262728293031log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0510152025303540455055600-5-10-15-20-25-30-35-40-45-50-55-60proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GPX3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYOGENESIS2.6e-602.2e-160.0513.6e-62.5e-61.3e-51.1e-82.3e-95.5e-64.5e-42.2e-16
ESTIMATE: StromalScore3e-501.8e-80.0326.3e-92.2e-161.0e-51.2e-70.0275.7e-40.0762.2e-16
xcell: stroma score5.6e-473.8e-100.0982e-72.9e-33.4e-67e-81.1e-52.2e-52e-73e-8
HALLMARK_UV_RESPONSE_DN5.2e-408.8e-90.122.7e-47.7e-71.1e-61.9e-73.5e-44.2e-48.7e-38e-10
xcell: Hematopoietic stem cell4.7e-392.1e-90.0311.7e-3-0.956.4e-111.4e-52.2e-163.7e-35.1e-39.8e-8
PROGENy: TGFb8.4e-392e-80.0294.1e-62.3e-73.7e-43.9e-80.0332.4e-42.1e-31.3e-8
xcell: Cancer associated fibroblast1.3e-367.5e-60.0821.4e-60.994.2e-71.3e-64.6e-62.1e-53.0e-63.6e-8
HALLMARK_KRAS_SIGNALING_UP4e-341.1e-31.3e-34.7e-62.2e-163.1e-34.4e-50.0758.3e-50.0242.3e-5
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION5.5e-334.6e-70.0511.1e-65.1e-113.8e-33.5e-60.545.3e-40.16.9e-10
HALLMARK_APICAL_JUNCTION6.9e-313.0e-60.0240.016.3e-76.1e-36e-77.1e-31.8e-40.0193e-8
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GPX3

BRCA0.450.15-0.09proteinmRNASCNVmethylationCCRCC0.030.17-0.19-0.010.33-0.07proteinmRNASCNVmethylationCOAD0.510.120.02proteinmRNASCNVmethylationGBM0.530.14-0.200.09-0.28-0.13proteinmRNASCNVmethylationHNSCC0.36-0.140.09-0.430.070.25proteinmRNASCNVmethylationLSCC0.410.080.160.160.370.41proteinmRNASCNVmethylationLUAD0.270.13-0.01-0.240.19-0.20proteinmRNASCNVmethylationOV0.37-0.130.16proteinmRNASCNVmethylationPDAC0.260.060.070.230.070.02proteinmRNASCNVmethylationUCEC0.340.070.110.080.01-0.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GPX3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.