Gene: GUCY2D

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
guanylate cyclase 2D, retinal
Ensembl
ENSG00000132518.7
Summary
This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]
Annotation
Druggable target (Tier T4) Protein Kinase Receptor

Protein product

  • ENST00000254854.5 Primary ENSP00000254854.4 (0 phosphosite)
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.1e-15-0.063--1.1e-51.9e-82.3e-7-0.57-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GUCY2D with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: Macrophage M2-----------
cibersort: Myeloid dendritic cell resting-----------
cibersort: Myeloid dendritic cell activated-----------
cibersort: Mast cell activated-----------
cibersort: Mast cell resting-----------
cibersort: Eosinophil-----------
cibersort: Neutrophil-----------
xcell: Myeloid dendritic cell activated-----------
xcell: B cell-----------
xcell: T cell CD4+ memory-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GUCY2D

BRCA-0.03proteinmRNASCNVmethylationCCRCC-0.040.04-0.09proteinmRNASCNVmethylationCOAD0.30proteinmRNASCNVmethylationGBM-0.15-0.020.10proteinmRNASCNVmethylationHNSCC0.000.160.24proteinmRNASCNVmethylationLSCC0.030.190.08proteinmRNASCNVmethylationLUAD0.140.21-0.07proteinmRNASCNVmethylationOV0.06proteinmRNASCNVmethylationPDAC-0.220.15-0.01proteinmRNASCNVmethylationUCEC-0.19-0.020.07proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GUCY2D and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.