Gene: GYPB

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
glycophorin B (MNS blood group)
Ensembl
ENSG00000250361.9
Summary
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. GYPB gene consists of 5 exons and has 97% sequence homology with GYPA from the 5' UTR to the coding sequence encoding the first 45 amino acids. In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

Protein product

  • ENST00000502664.6 Primary ENSP00000427690.1 (0 phosphosite)
  • ENST00000638448.1
  • ENST00000506516.6
  • ENST00000429670.3
  • ENST00000513128.5
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-3.8e-22-0.28---0.029-1.2e-19-1.5e-25--0.31-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC00.511.522.533.544.55log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456780-1-2-3-4-5-6-7-8Pan-cancer012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of GYPB with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: NK cell resting-----------
cibersort: NK cell activated-----------
cibersort: Monocyte-----------
cibersort: Macrophage M0-----------
cibersort: Macrophage M1-----------
cibersort: Macrophage M2-----------
cibersort: Myeloid dendritic cell resting-----------
cibersort: Myeloid dendritic cell activated-----------
cibersort: Mast cell activated-----------
cibersort: Mast cell resting-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of GYPB

BRCA-0.04proteinmRNASCNVmethylationCCRCC-0.03proteinmRNASCNVmethylationCOADproteinmRNASCNVmethylationGBM0.01proteinmRNASCNVmethylationHNSCC0.11proteinmRNASCNVmethylationLSCC0.18proteinmRNASCNVmethylationLUAD0.16proteinmRNASCNVmethylationOV0.11proteinmRNASCNVmethylationPDAC0.05proteinmRNASCNVmethylationUCEC-0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of GYPB and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.