Basic information

Full name
HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Ensembl
ENSG00000138642.15
Summary
HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.019-2.8e-3--0.9-0.240.49-8.6e-3-
protein5.8e-3----0.263.2e-30.71-0.250.004-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCAGBMHNSCCLSCCLUADOVPDACUCEC181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC05101520253035400-5-10-15-20-25-30-35-40Pan-cancer0204060801001201401601802002202400-20-40-60-80-100-120-140-160-180-200-220-240proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of HERC6 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: JAK-STAT7.6e-952.2e-16--2.2e-162.2e-162.2e-162.2e-162.3e-52.2e-167.1e-7
HALLMARK_INTERFERON_ALPHA_RESPONSE6.6e-862.2e-16--1.2e-92.2e-162.2e-162.2e-164.6e-52.2e-161.3e-5
HALLMARK_INTERFERON_GAMMA_RESPONSE2.6e-535.6e-8--1.4e-52.2e-162.2e-162.0e-61.9e-43.3e-72.2e-4
HALLMARK_IL6_JAK_STAT3_SIGNALING8.1e-165.2e-3--0.0531.7e-72.9e-40.0680.0120.0120.019
cibersort: Macrophage M11.6e-155.2e-4--0.0011.2e-57.5e-40.020.0971.1e-30.42
HALLMARK_INFLAMMATORY_RESPONSE6.1e-152.2e-3--0.0613.9e-70.0020.0428.1e-30.0690.014
HALLMARK_COMPLEMENT2e-122.2e-4--0.132.2e-58.2e-40.340.0150.0610.067
xcell: Myeloid dendritic cell activated6.5e-127.6e-3--1.3e-33.6e-50.0698.6e-30.0570.0740.2
PROGENy: NFkB1e-116.5e-3--0.0386.4e-39.9e-40.0810.0590.0544.3e-3
xcell: Macrophage M11.6e-102.9e-4--0.475.9e-74.2e-30.0820.0620.20.32
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of HERC6

BRCA0.70-0.04-0.03proteinmRNASCNVmethylationCCRCC0.20proteinmRNASCNVmethylationCOAD0.34proteinmRNASCNVmethylationGBM0.610.160.07proteinmRNASCNVmethylationHNSCC0.950.130.16proteinmRNASCNVmethylationLSCC0.85-0.000.11proteinmRNASCNVmethylationLUAD0.750.100.26proteinmRNASCNVmethylationOV0.610.140.23proteinmRNASCNVmethylationPDAC0.810.05-0.06proteinmRNASCNVmethylationUCEC0.66-0.030.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of HERC6 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.