Basic information

Full name
histone cell cycle regulator
Ensembl
ENSG00000100084.14
Summary
This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.6--6.6e-27--6.7e-103.2e-12-0.39--6.4e-3-
protein1.5e-16-3.0e-60.026-1.4e-36.7e-151.3e-58.5e-3-1.5e-30.095

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC88.599.51010.51111.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC18.51919.52020.52121.52222.52323.52424.525log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of HIRA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYC_TARGETS_V21e-131.4e-8-0.530.253.0e-60.979.9e-80.610.310.0196.3e-4
chromosomal instability7.7e-131.1e-3-0.67.1e-33.1e-30.192.2e-160.390.038-0.820.042
HALLMARK_E2F_TARGETS2.4e-123.3e-6-0.670.544e-7-0.454.5e-90.710.0910.0340.003
HALLMARK_G2M_CHECKPOINT1.4e-117.7e-50.870.421.0e-6-0.463.8e-70.690.150.0241.8e-3
HALLMARK_DNA_REPAIR2.4e-101.1e-4-0.190.266.9e-5-12.3e-70.150.0690.160.011
Tumor Purity (ABSOLUTE)3.1e-100.3-0.80.210.0070.0919.8e-100.980.0260.461.1e-5
xcell: T cell CD4+ Th19.4e-101.6e-7-0.980.243.9e-50.969.8e-3-0.960.190.0781.4e-3
KINASE-PSP_CDK22e-96.0e-40.530.294.8e-70.775.3e-3-0.740.360.019.9e-3
Tumor Purity (WGS)5.4e-8--0.61-2.1e-40.581e-110.65--0.182.4e-6
HALLMARK_MYC_TARGETS_V12.3e-73.6e-5-0.80.145.2e-4-0.371.9e-50.14-0.970.120.25
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of HIRA

BRCA0.530.260.39proteinmRNASCNVmethylationCCRCC0.150.10-0.01-0.230.19-0.18proteinmRNASCNVmethylationCOAD0.10-0.010.30proteinmRNASCNVmethylationGBM0.420.050.14-0.170.52-0.20proteinmRNASCNVmethylationHNSCC0.35-0.290.37-0.040.55-0.08proteinmRNASCNVmethylationLSCC0.39-0.190.41-0.230.61-0.25proteinmRNASCNVmethylationLUAD0.32-0.070.15-0.170.50-0.21proteinmRNASCNVmethylationOV0.190.060.73proteinmRNASCNVmethylationPDAC0.310.110.01-0.180.33-0.16proteinmRNASCNVmethylationUCEC0.350.15-0.11-0.020.01-0.16proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of HIRA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.