Basic information

Full name
heparan sulfate-glucosamine 3-sulfotransferase 1
Ensembl
ENSG00000002587.10
Summary
Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It possesses both heparan sulfate glucosaminyl 3-O-sulfotransferase activity, anticoagulant heparan sulfate conversion activity, and is a rate limiting enzyme for synthesis of anticoagulant heparan. This enzyme is an intraluminal Golgi resident protein. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000002596.6 Primary ENSP00000002596.5 (0 phosphosite)
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.8e-10-0.83---1.2e-72e-91.7e-12-2.7e-9-
protein3.0e-6-----1.8e-31.8e-64.2e-3-1.4e-6-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC3456789101112log2(RSEM+1)tumornormal
Protein expression
GBMHNSCCLSCCLUADPDAC15161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of HS3ST1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: Hypoxia1.3e-8---0.0250.260.214.9e-3-1.4e-7-
HALLMARK_GLYCOLYSIS3.4e-8---0.0190.260.175.3e-3-2.5e-6-
cibersort: Neutrophil7.9e-7---1.2e-30.0550.0320.019-0.16-
HALLMARK_HYPOXIA5.8e-6---9.3e-30.60.320.2-2.2e-6-
HALLMARK_MTORC1_SIGNALING1.7e-5---0.0120.15-0.640.07-1.7e-5-
PROGENy: TNFa3.1e-5---0.0150.10.420.08-6.8e-3-
PROGENy: PI3K8.1e-5---0.210.0770.230.015-0.031-
PROGENy: NFkB1.8e-4---0.010.10.550.11-0.048-
PROGENy: MAPK5.3e-4---0.750.0530.440.14-1.2e-3-
xcell: Neutrophil9.2e-4---0.170.0420.0210.76-0.17-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of HS3ST1

BRCA0.05proteinmRNASCNVmethylationCCRCC0.090.17-0.09proteinmRNASCNVmethylationCOAD0.37proteinmRNASCNVmethylationGBM0.27-0.09-0.11-0.090.00-0.09proteinmRNASCNVmethylationHNSCC0.22-0.14-0.050.100.100.20proteinmRNASCNVmethylationLSCC0.51-0.210.130.030.400.25proteinmRNASCNVmethylationLUAD0.410.14-0.100.030.270.02proteinmRNASCNVmethylationOV-0.06proteinmRNASCNVmethylationPDAC0.38-0.160.13-0.180.050.10proteinmRNASCNVmethylationUCEC-0.07-0.040.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of HS3ST1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.