Basic information

Full name
iduronate 2-sulfatase
Ensembl
ENSG00000010404.18
Summary
This gene encodes a member of the sulfatase family of proteins. The encoded preproprotein is proteolytically processed to generate two polypeptide chains. This enzyme is involved in the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this gene are associated with the X-linked lysosomal storage disease mucopolysaccharidosis type II, also known as Hunter syndrome. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]

Protein product

  • ENST00000340855.11 Primary ENSP00000339801.6 (0 phosphosite)
  • ENST00000370441.8
  • ENST00000428056.6
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.022-2.6e-16--3.0e-4-6.9e-16-0.77-0.095-
protein-1.0e-4-4.6e-6--0.3-5.3e-33-2.3e-27-0.033-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.51313.51414.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADOVPDACUCEC16171819202122232425log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112130-1-2-3-4-5-6-7-8-9-10-11-12-13Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of IDS with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_APICAL_JUNCTION3.3e-60.170.17--0.270.0832.0e-64.8e-30.930.580.017
HALLMARK_IL2_STAT5_SIGNALING4.4e-60.222.3e-3--0.310.841.0e-66.7e-3-0.9-0.351.7e-4
HALLMARK_COAGULATION5.6e-60.459.8e-4--0.510.0352.4e-80.22-0.84-0.215.4e-3
HALLMARK_COMPLEMENT6.0e-60.271.3e-4--0.580.585.7e-74.7e-3-0.42-0.0533.6e-4
HALLMARK_KRAS_SIGNALING_UP6.7e-60.480.031--0.520.467.6e-90.005-0.76-0.214.5e-4
xcell: Myeloid dendritic cell7.8e-60.476.6e-3--0.650.487.5e-60.0180.90.370.066
xcell: Macrophage2.4e-50.171.3e-5--0.740.0791.0e-50.002-0.24-0.0480.25
ESTIMATE: ImmuneScore2.7e-50.131.0e-4--0.460.861.5e-57.7e-3-0.49-0.249.5e-3
cibersort: Macrophage M24.4e-50.730.16--0.520.161.9e-48.3e-40.980.0620.42
KINASE-PSP_PKACA/PRKACA4.4e-50.033-0.91--0.370.0632.3e-30.0070.14-0.444.6e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of IDS

BRCA0.230.030.25proteinmRNASCNVmethylationCCRCC0.23-0.070.18-0.030.38-0.16proteinmRNASCNVmethylationCOAD0.18proteinmRNASCNVmethylationGBM0.69-0.040.08-0.070.18-0.04proteinmRNASCNVmethylationHNSCC0.420.080.01-0.080.29-0.33proteinmRNASCNVmethylationLSCC0.620.030.100.010.14-0.39proteinmRNASCNVmethylationLUAD0.650.150.180.230.37-0.13proteinmRNASCNVmethylationOV0.440.230.28proteinmRNASCNVmethylationPDAC0.32-0.020.08-0.070.19-0.34proteinmRNASCNVmethylationUCEC0.51-0.070.06-0.230.080.23proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of IDS and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.