Basic information
- Full name
- interleukin 12A
- Ensembl
- ENSG00000168811.7
- Summary
- This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
- Annotation
- Ligand
Protein product
- ENST00000305579.7 Primary ENSP00000303231.2 (0 phosphosite)
- ENST00000466512.1
- ENST00000480787.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -9.8e-14 | - | 1.0e-4 | - | - | -3.5e-13 | -0.055 | -2.2e-15 | - | -6.5e-4 | - |
protein | - | - | - | - | - | - | - | - | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of IL12A with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
cibersort: T cell CD4+ memory activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: T cell follicular helper | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: NK cell resting | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: NK cell activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Macrophage M0 | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Myeloid dendritic cell resting | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Myeloid dendritic cell activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Mast cell activated | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Mast cell resting | - | - | - | - | - | - | - | - | - | - | - | |
cibersort: Eosinophil | - | - | - | - | - | - | - | - | - | - | - |
Cis-association
Associations between omics data of IL12A
Trans-association
Associations of the protein abundance of IL12A and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.