Gene: IL15

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
interleukin 15
Ensembl
ENSG00000164136.17
Summary
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively spliced transcript variants of this gene have been reported. [provided by RefSeq, Feb 2011]
Annotation
Ligand

Protein product

  • ENST00000320650.9 Primary ENSP00000323505.4 (0 phosphosite)
  • ENST00000296545.11
  • ENST00000529613.5
  • ENST00000477265.5
  • ENST00000394159.2
  • ENST00000514653.5
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.29-8.5e-10--5.8e-9-1.8e-7-5.9e-15--0.19-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC3.544.555.566.577.588.599.51010.5log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0246810121416180-2-4-6-8-10-12-14-16-18Pan-cancer01020304050607080901000-10-20-30-40-50-60-70-80-90-100proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of IL15 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: B cell plasma-----------
cibersort: T cell CD4+ memory resting-----------
cibersort: T cell regulatory (Tregs)-----------
cibersort: NK cell activated-----------
cibersort: Macrophage M2-----------
xcell: immune score-----------
xcell: stroma score-----------
xcell: microenvironment score-----------
ESTIMATE: StromalScore-----------
ESTIMATE: ImmuneScore-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of IL15

BRCA-0.16proteinmRNASCNVmethylationCCRCC-0.040.100.23proteinmRNASCNVmethylationCOAD0.27proteinmRNASCNVmethylationGBM-0.170.10-0.07proteinmRNASCNVmethylationHNSCC0.120.260.20proteinmRNASCNVmethylationLSCC0.140.410.26proteinmRNASCNVmethylationLUAD-0.040.23-0.05proteinmRNASCNVmethylationOV0.44proteinmRNASCNVmethylationPDAC0.220.25-0.10proteinmRNASCNVmethylationUCEC0.03-0.010.11proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of IL15 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.