Gene: IL3RA

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
interleukin 3 receptor subunit alpha
Ensembl
ENSG00000185291.12
Summary
The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y. Alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jun 2012]
Annotation
Receptor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-3.2e-13-2.6e-26--0.019-1.5e-33-9.5e-34--7.5e-3-
protein-6.5e-47------4.1e-30-3.9e-19---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC234567891011log2(RSEM+1)tumornormal
Protein expression
CCRCCHNSCCLSCCLUADPDACUCEC1314151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer01020304050607080900-10-20-30-40-50-60-70-80-90proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of IL3RA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: T cell CD8+3.4e-12-0.24--2.2e-160.126.5e-3---
HALLMARK_ALLOGRAFT_REJECTION1.9e-11-0.18--5.2e-52.9e-80.016---
ESTIMATE: ImmuneScore3.9e-11-0.1--3.7e-44e-90.037---
xcell: microenvironment score9.8e-11-0.31--2.2e-32.6e-100.011---
xcell: immune score1.2e-10-0.25--0.0011e-90.018---
HALLMARK_IL6_JAK_STAT3_SIGNALING3.6e-9-0.88--7.4e-43.4e-71.6e-3---
ESTIMATE: ESTIMATEScore7.9e-9-0.66--0.0163.4e-96.8e-3---
HALLMARK_COMPLEMENT1.2e-8-0.61--8.2e-37e-86.6e-3---
xcell: Endothelial cell1.4e-8-0.71--0.0579.2e-97.5e-4---
xcell: Myeloid dendritic cell5.1e-8-0.33--1.5e-48.7e-90.58---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of IL3RA

BRCA0.25proteinmRNASCNVmethylationCCRCC0.150.050.01proteinmRNASCNVmethylationCOAD0.07proteinmRNASCNVmethylationGBM0.19proteinmRNASCNVmethylationHNSCC0.840.320.41proteinmRNASCNVmethylationLSCC0.670.170.14proteinmRNASCNVmethylationLUAD0.42-0.30-0.06proteinmRNASCNVmethylationOV0.19proteinmRNASCNVmethylationPDAC0.15proteinmRNASCNVmethylationUCEC0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of IL3RA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.