Gene: INPP5D

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
inositol polyphosphate-5-phosphatase D
Ensembl
ENSG00000168918.14
Summary
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Annotation
Druggable target (Tier T3) Phosphatase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.7e-3-1.9e-27---0.49-1.2e-11-8.4e-7--0.033-
protein1.4e-17-2.5e-261.1e-12-2.3e-5-0.021-0.95-0.851.4e-40.35

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC4567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2222.52323.52424.52525.52626.527log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer0204060801001201400-20-40-60-80-100-120-140proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of INPP5D with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore4.9e-1232.2e-162.2e-160.472.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-16
HALLMARK_ALLOGRAFT_REJECTION7.1e-1232.2e-162.2e-160.52.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-16
xcell: immune score1.1e-1162.2e-162.2e-160.282.2e-162.2e-162.2e-162.2e-162.2e-164.4e-92.2e-16
ESTIMATE: ESTIMATEScore3.0e-1092.2e-162.2e-160.442.2e-162.2e-162.2e-161.8e-92.2e-162.4e-92.2e-16
xcell: microenvironment score2.7e-1062.2e-162.2e-160.242.2e-162.2e-162.2e-162.2e-162.2e-161.3e-79.6e-8
HALLMARK_COMPLEMENT2.2e-1052.2e-162.2e-160.972.2e-161.6e-202.2e-163.1e-62.2e-161.2e-82.2e-16
HALLMARK_IL6_JAK_STAT3_SIGNALING2.2e-1012.2e-162.2e-16-0.752.2e-162.2e-162.2e-163.9e-82.2e-166.7e-72.2e-16
HALLMARK_INFLAMMATORY_RESPONSE3.9e-962.2e-162.2e-16-0.272.2e-162.2e-162.2e-161.1e-62.2e-165.1e-62.2e-16
HALLMARK_IL2_STAT5_SIGNALING1.4e-922.2e-162.8e-80.892.2e-162.2e-162.2e-161.5e-82.2e-168.5e-52.2e-16
HALLMARK_INTERFERON_GAMMA_RESPONSE2e-832.2e-162.2e-16-0.958.7e-92.2e-162.2e-167.4e-65.3e-93.5e-52.2e-16
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of INPP5D

BRCA0.790.200.13proteinmRNASCNVmethylationCCRCC0.72-0.410.07-0.390.090.11proteinmRNASCNVmethylationCOAD0.590.140.07proteinmRNASCNVmethylationGBM0.82-0.39-0.01-0.260.050.15proteinmRNASCNVmethylationHNSCC0.88-0.490.15-0.500.19-0.08proteinmRNASCNVmethylationLSCC0.89-0.550.31-0.450.34-0.09proteinmRNASCNVmethylationLUAD0.70-0.250.04-0.100.150.11proteinmRNASCNVmethylationOV0.57-0.12-0.08proteinmRNASCNVmethylationPDAC0.78-0.470.10-0.420.090.02proteinmRNASCNVmethylationUCEC0.80-0.670.01-0.550.070.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of INPP5D and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.