Basic information

Full name
integrin subunit alpha 11
Ensembl
ENSG00000137809.17
Summary
This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T4) Receptor

Protein product

  • ENST00000315757.9 Primary ENSP00000327290.7 (0 phosphosite)
  • ENST00000423218.6
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.6e-39--1.9e-4--5.4e-72.6e-272.9e-33-1.9e-7-
protein3e-27-7.4e-36.4e-4-2.2e-108.9e-211.6e-14-6.3e-32.2e-11-4.5e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC234567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC15161718192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer0204060801001201401600-20-40-60-80-100-120-140-160proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ITGA11 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION1.4e-812.2e-160.0013.5e-45.6e-35.7e-82.2e-162.2e-162.2e-161.1e-52.2e-16
PROGENy: TGFb4.1e-672.2e-163.2e-45.1e-47.3e-32.6e-62.2e-161.2e-92.2e-168.7e-51.7e-8
ESTIMATE: StromalScore6e-531.4e-72.7e-44.5e-45.8e-30.012.9e-73.4e-62.2e-167.0e-62.2e-16
HALLMARK_ANGIOGENESIS4.3e-383.5e-83.3e-31.4e-33.3e-31.2e-33.4e-31.5e-72.2e-160.17e-7
HALLMARK_APICAL_JUNCTION3.8e-302.7e-51.5e-30.030.0690.277.5e-64.1e-42.2e-160.0361.1e-7
HALLMARK_MYOGENESIS8.8e-296.7e-62.4e-50.0460.082-0.697.9e-60.0178.6e-100.0522.2e-16
HALLMARK_COAGULATION2.7e-251.9e-70.0370.0010.0250.0266.3e-30.0343.4e-100.0191.5e-5
HALLMARK_UV_RESPONSE_DN1e-241.2e-40.0230.0190.084.2e-53.7e-60.0295.1e-90.472.0e-6
HALLMARK_TGF_BETA_SIGNALING2.2e-213.8e-60.0160.0168.4e-30.222.5e-50.423.2e-110.133.7e-4
HALLMARK_HYPOXIA2.4e-183.3e-50.670.0350.0310.0052.2e-30.0612.5e-89.4e-34.3e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ITGA11

BRCA0.79-0.04-0.04proteinmRNASCNVmethylationCCRCC0.620.12-0.02-0.090.020.04proteinmRNASCNVmethylationCOAD0.450.06-0.03proteinmRNASCNVmethylationGBM0.520.210.130.310.150.07proteinmRNASCNVmethylationHNSCC0.83-0.27-0.13-0.18-0.100.08proteinmRNASCNVmethylationLSCC0.84-0.000.170.040.120.01proteinmRNASCNVmethylationLUAD0.780.14-0.120.16-0.090.04proteinmRNASCNVmethylationOV0.860.110.09proteinmRNASCNVmethylationPDAC0.70-0.070.08-0.130.22-0.00proteinmRNASCNVmethylationUCEC0.75-0.04-0.00-0.15-0.17-0.15proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ITGA11 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.