Gene: ITGB2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
integrin subunit beta 2
Ensembl
ENSG00000160255.18
Summary
This gene encodes an integrin beta chain, which combines with multiple different alpha chains to form different integrin heterodimers. Integrins are integral cell-surface proteins that participate in cell adhesion as well as cell-surface mediated signalling. The encoded protein plays an important role in immune response and defects in this gene cause leukocyte adhesion deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Annotation
Druggable target (Tier T3) Receptor

Protein product

  • ENST00000652462.1 Primary ENSP00000498780.1 (5 phosphosites)
  • ENST00000397850.6
  • ENST00000355153.8
  • ENST00000397857.5
  • ENST00000397852.5
  • ENST00000302347.10
  • ENST00000397854.7
  • ENST00000397846.7
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.4-5.2e-28--2.5e-9-5.2e-14-0.001--0.14-
protein3.3e-30-6.8e-283.8e-12-1.3e-20-0.0850.69-0.675.1e-80.16

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC6789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2323.52424.52525.52626.52727.52828.52929.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530354045500-5-10-15-20-25-30-35-40-45-50Pan-cancer0204060801001201401601802002200-20-40-60-80-100-120-140-160-180-200-220proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ITGB2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_IL6_JAK_STAT3_SIGNALING3.3e-1402.2e-162.2e-162.2e-162.2e-162.2e-162.2e-165.3e-92.2e-162.2e-162.2e-16
HALLMARK_INFLAMMATORY_RESPONSE4.4e-1282.2e-161.5e-72.2e-162.2e-162.2e-162.2e-161.8e-72.2e-162.2e-162.2e-16
ESTIMATE: ImmuneScore1.2e-1072.2e-164.7e-91.8e-72.2e-162.2e-162.2e-163.0e-52.2e-162.1e-72.2e-16
HALLMARK_ALLOGRAFT_REJECTION5.8e-1072.2e-164.2e-91.2e-72.2e-162.2e-162.2e-167.7e-62.2e-164.7e-62.2e-16
PROGENy: NFkB1.1e-1064.7e-101.9e-52.2e-162.2e-162.2e-162.2e-162.5e-87.7e-92.2e-169.2e-11
HALLMARK_COMPLEMENT9.6e-1032.2e-161.6e-82.2e-162.2e-163.2e-92.2e-167.4e-62.2e-169.4e-81.9e-8
xcell: immune score2.3e-1002.2e-162.2e-161.6e-52.2e-162.2e-162.2e-161.3e-32.2e-162.1e-71.3e-7
xcell: Macrophage2.7e-993.2e-152.2e-161.4e-72.2e-162e-71.2e-112.5e-77.8e-92.2e-165.6e-10
PROGENy: TNFa2.5e-962e-81.5e-52.2e-162.2e-169.3e-102.2e-169.8e-81.4e-82.2e-162.7e-9
xcell: Macrophage M19.2e-892.2e-161.7e-91.1e-52.2e-169.2e-82.2e-168.2e-81.1e-97.5e-83e-9
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ITGB2

BRCA0.650.170.20proteinmRNASCNVmethylationCCRCC0.690.160.09proteinmRNASCNVmethylationCOAD0.52-0.01-0.20proteinmRNASCNVmethylationGBM0.860.010.05proteinmRNASCNVmethylationHNSCC0.530.140.29proteinmRNASCNVmethylationLSCC0.660.200.25proteinmRNASCNVmethylationLUAD0.480.080.15proteinmRNASCNVmethylationOV0.55-0.14-0.12proteinmRNASCNVmethylationPDAC0.560.120.25proteinmRNASCNVmethylationUCEC0.630.05-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ITGB2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.