Gene: ITK

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
IL2 inducible T cell kinase
Ensembl
ENSG00000113263.13
Summary
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Annotation
Druggable target (Tier T3) Protein Kinase

Protein product

  • ENST00000422843.8 Primary ENSP00000398655.4 (0 phosphosite)
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.063-2.5e-19--0.012-4e-11-2.5e-11--0.11-
protein-0.93------0.93----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC12345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCALSCCPDAC1515.51616.51717.51818.51919.52020.52121.522log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC05101520253035404550550-5-10-15-20-25-30-35-40-45-50-55Pan-cancer0204060801001201401601802002202400-20-40-60-80-100-120-140-160-180-200-220-240proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ITK with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_ALLOGRAFT_REJECTION4.3e-70.32----1.2e-7--0.014-
xcell: T cell CD8+ central memory7.5e-70.15----1.1e-8--0.15-
ESTIMATE: ImmuneScore1.1e-60.28----2e-7--0.031-
xcell: B cell1.8e-60.11----3.5e-7--0.11-
HALLMARK_IL2_STAT5_SIGNALING2.0e-60.23----4.2e-5--3.5e-3-
ESTIMATE: ESTIMATEScore2.3e-60.14----2.4e-5--0.014-
HALLMARK_COMPLEMENT2.4e-60.1----1.0e-4--8.2e-3-
HALLMARK_IL6_JAK_STAT3_SIGNALING3.3e-60.46----2.4e-5--0.002-
xcell: T cell CD8+7.2e-60.039----6.3e-6--0.23-
xcell: microenvironment score1.5e-50.044----5.0e-5--0.15-
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* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ITK

BRCA0.130.22-0.18proteinmRNASCNVmethylationCCRCC0.01proteinmRNASCNVmethylationCOAD0.15proteinmRNASCNVmethylationGBM-0.26proteinmRNASCNVmethylationHNSCC0.38proteinmRNASCNVmethylationLSCC0.610.150.36proteinmRNASCNVmethylationLUAD-0.07proteinmRNASCNVmethylationOV0.10proteinmRNASCNVmethylationPDAC0.600.120.03proteinmRNASCNVmethylationUCEC0.17proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ITK and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.