Gene: KMT5A

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
lysine methyltransferase 5A
Ensembl
ENSG00000183955.13
Summary
The protein encoded by this gene is a protein-lysine N-methyltransferase that can monomethylate Lys-20 of histone H4 to effect transcriptional repression of some genes. The encoded protein is required for cell proliferation and plays a role in chromatin condensation. [provided by RefSeq, May 2016]
Annotation
Essential genes

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA6.9e-5-6.6e-3---1.1e-82.6e-22-0.56-5.8e-3-
protein0.76-3.5e-6----0.022-0.004---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC8.599.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMLSCCLUADOVUCEC13141516171819202122log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of KMT5A with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: T cell CD8+ effector memory1.7e-30.832.2e-4--0.78-0.740.0670.27-0.16
xcell: T cell gamma delta3.1e-30.533.2e-6-0.43--0.810.360.41-0.8
xcell: T cell CD4+ naive0.0110.90.82-0.37-0.660.137.3e-3-0.4
xcell: T cell CD4+ Th20.025-0.221.2e-4-0.51-0.530.18-0.67-0.27
xcell: Macrophage0.035-0.626.8e-3--0.84-0.210.660.4-0.3
xcell: Macrophage M10.037-0.235.9e-3-0.96-0.220.520.22-0.42
HALLMARK_ALLOGRAFT_REJECTION0.037-0.242.4e-5--0.96-0.46-0.960.13-0.73
KINASE-PSP_mTOR/MTOR0.0430.27--0.34-----0.15
xcell: Eosinophil0.0430.0260.91-0.047-0.12-0.610.077--0.074
ESTIMATE: ImmuneScore0.057-0.313.5e-5--0.93-0.35-0.940.34-0.84
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of KMT5A

BRCA-0.280.170.29proteinmRNASCNVmethylationCCRCC-0.230.060.13-0.160.17-0.19proteinmRNASCNVmethylationCOAD0.33proteinmRNASCNVmethylationGBM-0.11-0.000.19-0.060.23-0.01proteinmRNASCNVmethylationHNSCC-0.030.17-0.09proteinmRNASCNVmethylationLSCC-0.000.02-0.02-0.030.36-0.17proteinmRNASCNVmethylationLUAD0.07-0.03-0.09-0.200.69-0.25proteinmRNASCNVmethylationOV0.370.550.63proteinmRNASCNVmethylationPDAC0.090.62-0.13proteinmRNASCNVmethylationUCEC0.090.12-0.10-0.110.29-0.17proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of KMT5A and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.