Gene: LTF

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
lactotransferrin
Ensembl
ENSG00000012223.13
Summary
This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Annotation
Transcription factor Ligand

Protein product

  • ENST00000231751.9 Primary ENSP00000231751.4 (0 phosphosite)
  • ENST00000417439.5
  • ENST00000426532.6
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.87--1.3e-9---1.7e-33.3e-93.6e-5--0.63-
protein-0.44----0.380.71-9.3e-3---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCHNSCCLSCCLUADPDAC1314151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28Pan-cancer02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of LTF with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: Neutrophil9.3e-12-1---0.522.2e-131.3e-9-0.23-
PROGENy: TNFa1.3e-100.13---0.553.1e-79.1e-9-0.16-
PROGENy: NFkB2.8e-90.17---0.52.9e-63.6e-8-0.3-
PROGENy: PI3K8.6e-70.025---0.730.0134.2e-5-0.064-
HALLMARK_TNFA_SIGNALING_VIA_NFKB9e-70.33---0.561.2e-64.2e-5-0.65-
HALLMARK_GLYCOLYSIS2.7e-60.14---0.10.15.7e-4-0.021-
HALLMARK_HYPOXIA4.0e-60.035----0.89.9e-58.0e-5-0.53-
PROGENy: Hypoxia9.2e-60.11----0.754.7e-39.7e-4-0.012-
xcell: Monocyte1.7e-5-0.99---0.731.9e-70.013-0.11-
xcell: Neutrophil1.9e-50.38---0.771.1e-80.13-0.25-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of LTF

BRCA0.530.04-0.10proteinmRNASCNVmethylationCCRCC-0.230.27-0.05proteinmRNASCNVmethylationCOAD0.05proteinmRNASCNVmethylationGBM-0.23-0.000.15proteinmRNASCNVmethylationHNSCC0.45-0.060.100.100.260.17proteinmRNASCNVmethylationLSCC0.36-0.080.060.230.300.35proteinmRNASCNVmethylationLUAD0.210.250.05-0.010.140.17proteinmRNASCNVmethylationOV-0.01proteinmRNASCNVmethylationPDAC-0.310.27-0.350.010.140.30proteinmRNASCNVmethylationUCEC-0.380.110.12proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of LTF and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.