Gene: LTK

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
leukocyte receptor tyrosine kinase
Ensembl
ENSG00000062524.16
Summary
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Annotation
IDG target Druggable target (Tier T4) Protein Kinase

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-4.5e-21--5.7e-18---0.012-4.4e-15-7.1e-3-0.53-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011log2(RSEM+1)tumornormal
Protein expression
LSCC12.612.81313.213.413.613.81414.214.414.614.81515.215.415.6log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer012345678910111213140-1-2-3-4-5-6-7-8-9-10-11-12-13-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of LTK with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: B cell memory-----------
cibersort: T cell CD4+ naive-----------
cibersort: T cell follicular helper-----------
cibersort: NK cell resting-----------
cibersort: Macrophage M0-----------
cibersort: Myeloid dendritic cell resting-----------
cibersort: Mast cell resting-----------
xcell: Myeloid dendritic cell activated-----------
xcell: T cell CD4+ naive-----------
xcell: T cell CD4+ effector memory-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of LTK

BRCA0.08proteinmRNASCNVmethylationCCRCC0.01proteinmRNASCNVmethylationCOAD0.43proteinmRNASCNVmethylationGBM0.16proteinmRNASCNVmethylationHNSCC0.04proteinmRNASCNVmethylationLSCC0.02proteinmRNASCNVmethylationLUAD0.04proteinmRNASCNVmethylationOV0.09proteinmRNASCNVmethylationPDAC0.17proteinmRNASCNVmethylationUCEC0.02proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of LTK and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.