Basic information

Full name
macrophage erythroblast attacher, E3 ubiquitin ligase
Ensembl
ENSG00000090316.16
Summary
This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.42--1.6e-16---0.0618.5e-34.9e-15-0.15-
protein2.7e-10--0.0240.083--0.0722.1e-143.3e-5-2.9e-52.2e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456780-1-2-3-4-5-6-7-8Pan-cancer0123456789101112130-1-2-3-4-5-6-7-8-9-10-11-12-13proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MAEA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_G2M_CHECKPOINT3.5e-135.7e-40.0350.140.0367.0e-46.5e-70.0850.310.10.26
KINASE-PSP_CDK24.2e-123.3e-40.130.390.0552.2e-45.7e-40.0210.420.0330.095
HALLMARK_E2F_TARGETS6.3e-111.8e-30.0450.360.083.7e-31.1e-60.210.20.0780.42
HALLMARK_SPERMATOGENESIS4.5e-100.012-0.930.770.10.0081e-72.6e-30.180.110.16
PERT-PSP_NOCODAZOLE3e-92.3e-4-0.76-0.390.41.3e-63.1e-70.180.0370.430.22
chromosomal instability8.5e-90.013.2e-4-0.140.982.9e-41.7e-80.170.630.510.087
KINASE-PSP_CDK19.7e-97.5e-4-0.450.0650.164.4e-42.7e-40.150.180.320.18
Tumor Purity (WGS)4.2e-8-0.17-0.814.0e-58.8e-80.11-0.570.2
HALLMARK_MITOTIC_SPINDLE1.0e-62.4e-30.590.0250.120.136.3e-30.440.940.120.16
HALLMARK_MYC_TARGETS_V21.1e-60.140.0640.20.690.0122.5e-70.66-0.970.210.28
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MAEA

BRCA-0.06-0.030.48proteinmRNASCNVmethylationCCRCC-0.070.01-0.24-0.180.27-0.02proteinmRNASCNVmethylationCOAD0.210.060.56proteinmRNASCNVmethylationGBM0.290.100.000.000.24-0.19proteinmRNASCNVmethylationHNSCC0.04-0.10-0.02-0.170.61-0.17proteinmRNASCNVmethylationLSCC0.040.09-0.210.000.73-0.02proteinmRNASCNVmethylationLUAD-0.05-0.10-0.01-0.010.62-0.03proteinmRNASCNVmethylationOV0.02-0.130.69proteinmRNASCNVmethylationPDAC0.10-0.05-0.01-0.330.33-0.06proteinmRNASCNVmethylationUCEC-0.05-0.03-0.19-0.150.360.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MAEA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.