Gene: MAPK10

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
mitogen-activated protein kinase 10
Ensembl
ENSG00000109339.24
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Annotation
Druggable target (Tier T3) Protein Kinase

Protein product

  • ENST00000641462.2 Primary ENSP00000493435.1 (0 phosphosite)
  • ENST00000641983.1
  • ENST00000641066.1
  • ENST00000641051.1
  • ENST00000641952.1
  • ENST00000641341.1
  • ENST00000638313.1
  • ENST00000641902.1
  • ENST00000641647.1
  • ENST00000641207.1
  • ENST00000641823.1
  • ENST00000641157.1
  • ENST00000515650.2
  • ENST00000515400.3
  • ENST00000638225.1
  • ENST00000641803.1
  • ENST00000641943.1
  • ENST00000641657.1
  • ENST00000641287.1
  • ENST00000642015.1
  • ENST00000642103.1
  • ENST00000639242.1
  • ENST00000395166.6
  • ENST00000641297.1
  • ENST00000641724.1
  • ENST00000641283.1
  • ENST00000641110.1
  • ENST00000641737.1
  • ENST00000639175.1
  • ENST00000641391.1
  • ENST00000642009.1
  • ENST00000641911.1
  • ENST00000641166.1
  • ENST00000641677.1
  • ENST00000641485.1
  • ENST00000395169.9
  • ENST00000395160.9
  • ENST00000641050.1
  • ENST00000641170.1
  • ENST00000640858.1
  • ENST00000639234.1
  • ENST00000395157.9
  • ENST00000640970.1
  • ENST00000641862.1
  • ENST00000642038.1
  • ENST00000641274.1
  • ENST00000641493.1
  • ENST00000641762.1
  • ENST00000641405.1
  • ENST00000361569.8
  • ENST00000641384.1
  • ENST00000641208.1
  • ENST00000641120.1
  • ENST00000641864.1
  • ENST00000641102.1
  • ENST00000641767.1
  • ENST00000642032.1
  • ENST00000641237.1
  • ENST00000639972.2
  • ENST00000640490.1
  • ENST00000359221.8
  • ENST00000641555.1
  • ENST00000641537.1
  • ENST00000512689.6
  • ENST00000641313.1
  • ENST00000641989.1
  • ENST00000641430.1
  • ENST00000642013.1
  • ENST00000641052.1
  • ENST00000641020.1
  • ENST00000642023.1
  • ENST00000641217.1
  • ENST00000641607.1
  • ENST00000642006.1
  • ENST00000641047.1
  • ENST00000511167.6
  • ENST00000513186.7
  • ENST00000641777.1
  • ENST00000449047.8
  • ENST00000641010.1
  • ENST00000641459.1
  • ENST00000641553.1
  • ENST00000641718.1
  • ENST00000641831.1
  • ENST00000641954.1
  • ENST00000641324.1
  • ENST00000641903.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.6e-38--7.4e-29---0.28-1.4e-3-4.7e-17--3e-7-
protein-6.1e-7--6.0e-6----0.044-2e-80.2-0.78-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC34567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMLSCCLUADOVPDACUCEC1617181920212223242526log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer0510152025300-5-10-15-20-25-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MAPK10 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
DISEASE-PSP_Alzheimer's_disease1.1e-12---2.2e-16-----0.064
HALLMARK_MYOGENESIS2e-70.0670.250.430.2-0.130.460.130.121.7e-7
HALLMARK_HEDGEHOG_SIGNALING4.0e-50.15-0.120.312.6e-3-0.60.330.677.9e-31.3e-4
xcell: stroma score5.3e-50.230.10.250.85--0.31-0.380.220.72.2e-16
PROGENy: TGFb3.0e-40.120.620.560.9--0.51-0.990.520.0196.8e-9
xcell: Eosinophil3.9e-40.0850.130.0410.008-10.250.920.13-0.95
xcell: Hematopoietic stem cell4.7e-40.280.150.340.31--0.460.350.051-0.896.6e-5
HALLMARK_HEME_METABOLISM0.0010.25.2e-60.690.032-0.0740.65-0.620.79-0.6
HALLMARK_KRAS_SIGNALING_DN1.2e-30.280.620.96.3e-5-5.7e-30.760.87-0.780.28
HALLMARK_APICAL_JUNCTION1.6e-30.05-0.98-0.99-0.8-0.62-0.650.470.0135.8e-6
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MAPK10

BRCA0.560.180.37proteinmRNASCNVmethylationCCRCC0.51-0.190.25-0.010.300.15proteinmRNASCNVmethylationCOAD0.320.14-0.16proteinmRNASCNVmethylationGBM0.64-0.120.06-0.09-0.04-0.07proteinmRNASCNVmethylationHNSCC-0.070.08-0.27proteinmRNASCNVmethylationLSCC0.70-0.120.14-0.100.210.17proteinmRNASCNVmethylationLUAD0.18-0.590.29-0.020.230.01proteinmRNASCNVmethylationOV-0.030.070.28proteinmRNASCNVmethylationPDAC0.220.110.03-0.100.10-0.04proteinmRNASCNVmethylationUCEC0.66-0.130.05-0.17-0.090.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MAPK10 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.