Basic information

Full name
mesoderm specific transcript
Ensembl
ENSG00000106484.16
Summary
This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

Protein product

  • ENST00000223215.10 Primary ENSP00000223215.4 (0 phosphosite)
  • ENST00000341441.9
  • ENST00000393187.5
  • ENST00000462132.6
  • ENST00000437945.6
  • ENST00000427521.6
  • ENST00000416162.7
  • ENST00000378576.9
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.4e-10--3.1e-20--1.5e-72.4e-213.9e-17--0.55-
protein0.16--7.7e-30.058-0.469.4e-3-0.5-0.092.2e-5-0.63

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC345678910111213141516log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1819202122232425262728log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MEST with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TGFb2.2e-70.253.0e-40.01-0.360.470.120.351.3e-40.0130.66
HALLMARK_HEDGEHOG_SIGNALING1.2e-60.520.0292.6e-30.650.0730.087-0.372.1e-50.130.48
HALLMARK_WNT_BETA_CATENIN_SIGNALING3.7e-60.110.0193.7e-4-0.320.640.860.22.2e-40.280.14
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION1.3e-50.215.0e-50.016-0.850.960.410.891.3e-30.0640.85
HALLMARK_NOTCH_SIGNALING4.0e-50.291.6e-47.8e-3-0.780.160.6-0.0290.0113.6e-30.57
KINASE-PSP_JNK1/MAPK85.7e-5---3.8e-4-----0.032
HALLMARK_APICAL_JUNCTION6.1e-50.575.0e-50.0120.860.750.61-0.0655.4e-50.0460.73
PROGENy: WNT1.4e-40.060.0710.0280.650.760.570.210.010.13-0.63
xcell: Cancer associated fibroblast1.6e-40.282.3e-30.85-0.960.550.12-0.111.0e-41.7e-30.94
HALLMARK_UV_RESPONSE_DN2.0e-40.244.7e-40.071-0.550.0560.35-0.695.9e-5-0.95-0.62
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MEST

BRCA0.620.290.34proteinmRNASCNVmethylationCCRCC0.32-0.21-0.02-0.330.20-0.14proteinmRNASCNVmethylationCOAD0.250.100.35proteinmRNASCNVmethylationGBM0.83-0.340.31-0.320.44-0.02proteinmRNASCNVmethylationHNSCC0.690.060.320.180.260.11proteinmRNASCNVmethylationLSCC0.670.040.210.180.350.09proteinmRNASCNVmethylationLUAD0.550.08-0.020.250.19-0.07proteinmRNASCNVmethylationOV0.620.290.34proteinmRNASCNVmethylationPDAC0.52-0.000.150.050.250.07proteinmRNASCNVmethylationUCEC0.560.000.160.100.280.06proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MEST and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.