Gene: MS4A2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
membrane spanning 4-domains A2
Ensembl
ENSG00000149534.9
Summary
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]
Annotation
Druggable target (Tier T2)

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.5e-15-1.4e-12---4.6e-3-2.2e-28-3.9e-27--0.91-
protein-1.5e-5-------1.5e-5---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1234567891011log2(RSEM+1)tumornormal
Protein expression
LSCCLUAD14.214.414.614.81515.215.415.615.81616.216.416.616.81717.2log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28Pan-cancer051015202530354045505560650-5-10-15-20-25-30-35-40-45-50-55-60-65proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MS4A2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Clinical: Path_Stage_pN0.027------0.027---
HALLMARK_COAGULATION0.068------0.068---
HALLMARK_CHOLESTEROL_HOMEOSTASIS0.072------0.072---
Clinical: Stage0.077------0.077---
KINASE-PSP_Chk1/CHEK10.079------0.079---
PROGENy: p530.085------0.085---
xcell: Macrophage M20.089------0.089---
HALLMARK_UNFOLDED_PROTEIN_RESPONSE0.11------0.11---
PROGENy: MAPK0.11------0.11---
xcell: Common lymphoid progenitor0.12------0.12---
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MS4A2

BRCA-0.08proteinmRNASCNVmethylationCCRCC0.18proteinmRNASCNVmethylationCOAD-0.04proteinmRNASCNVmethylationGBM-0.03proteinmRNASCNVmethylationHNSCC0.14proteinmRNASCNVmethylationLSCC0.12proteinmRNASCNVmethylationLUAD0.01-0.080.01proteinmRNASCNVmethylationOV-0.09proteinmRNASCNVmethylationPDAC0.08proteinmRNASCNVmethylationUCEC-0.14proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MS4A2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.