Gene: MUC1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
mucin 1, cell surface associated
Ensembl
ENSG00000185499.16
Summary
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Annotation
Receptor

Protein product

  • ENST00000611571.4 Primary ENSP00000480333.1 (16 phosphosites)
  • ENST00000368398.7
  • ENST00000438413.5
  • ENST00000611577.4
  • ENST00000343256.9
  • ENST00000368393.7
  • ENST00000615517.4
  • ENST00000368389.6
  • ENST00000342482.8
  • ENST00000368396.8
  • ENST00000471283.5
  • ENST00000612778.4
  • ENST00000462215.5
  • ENST00000614519.4
  • ENST00000620103.4
  • ENST00000337604.6
  • ENST00000457295.6
  • ENST00000368392.7
  • ENST00000368390.7
  • ENST00000338684.9
  • ENST00000610359.4
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-2.3e-9--1.7e-16---7.1e-8-2.1e-286.3e-13-3.7e-5-
protein-0.92--6e-180.4--4.4e-8-4.9e-281.1e-120.197.8e-155.1e-6

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC123456789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC171819202122232425262728293031log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer024681012141618202224260-2-4-6-8-10-12-14-16-18-20-22-24-26proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MUC1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_ANDROGEN_RESPONSE3e-172.4e-80.470.166.6e-53.0e-43.5e-93.2e-30.39-0.990.087
HALLMARK_HEME_METABOLISM8.4e-160.374.8e-39.0e-53.9e-60.21.8e-66.3e-40.140.830.039
HALLMARK_ESTROGEN_RESPONSE_EARLY2.3e-146.2e-92.0e-4-0.956.8e-70.0038.9e-70.0250.3-3.7e-40.036
HALLMARK_ESTROGEN_RESPONSE_LATE1.7e-131.5e-93.3e-30.445.1e-70.0063.8e-40.390.048-0.0080.039
PROGENy: Androgen7.1e-132.2e-16-0.920.510.0871.4e-46.6e-60.0160.12-0.0520.062
HALLMARK_COAGULATION1.3e-128.9e-45.7e-6-0.461.1e-50.762.2e-160.0250.79-0.93-0.99
HALLMARK_FATTY_ACID_METABOLISM2.9e-118.5e-5-0.640.0167.2e-60.0180.0847.8e-60.62-0.850.071
HALLMARK_ADIPOGENESIS7.5e-101.3e-40.59-0.299.4e-7-0.923.7e-101.6e-6-0.75-0.740.35
HALLMARK_PEROXISOME2.2e-95.4e-30.2-0.192.3e-40.0432.1e-31.4e-52.9e-3-0.0850.071
HALLMARK_GLYCOLYSIS3.1e-9-0.790.0290.0571.5e-30.270.210.220.0359.8e-60.11
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MUC1

BRCA0.74-0.10-0.09proteinmRNASCNVmethylationCCRCC0.71-0.07-0.06-0.080.07-0.26proteinmRNASCNVmethylationCOAD0.600.270.25proteinmRNASCNVmethylationGBM0.43-0.01-0.13-0.14-0.06-0.06proteinmRNASCNVmethylationHNSCC0.790.030.000.080.08-0.23proteinmRNASCNVmethylationLSCC0.840.09-0.260.01-0.23-0.46proteinmRNASCNVmethylationLUAD0.700.040.19-0.090.35-0.25proteinmRNASCNVmethylationOV0.230.090.08proteinmRNASCNVmethylationPDAC0.46-0.120.280.010.28-0.27proteinmRNASCNVmethylationUCEC0.64-0.150.19-0.110.27-0.51proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MUC1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.