Basic information
- Full name
- MUS81 structure-specific endonuclease subunit
- Ensembl
- ENSG00000172732.12
- Summary
- This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017]
Protein product
- ENST00000308110.9 Primary ENSP00000307853.4 (3 phosphosites)
- ENST00000533035.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 3.9e-18 | - | 6.4e-21 | - | - | 7.3e-5 | 0.53 | 1.0e-6 | - | 0.58 | - |
protein | -0.09 | - | - | - | - | - | -0.09 | - | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of MUS81 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
Tumor Purity (ABSOLUTE) | 1.2e-3 | 0.28 | - | - | - | 0.073 | 5.8e-3 | - | - | - | - | |
Tumor Purity (WGS) | 2.9e-3 | - | - | - | - | 0.064 | 0.018 | - | - | - | - | |
KINASE-PSP_CDK5 | 4.7e-3 | - | - | - | - | 0.11 | 0.017 | - | - | - | - | |
chromosomal instability | 0.024 | 0.1 | - | - | - | 0.8 | 0.042 | - | - | - | - | |
SBS5 (unknown) | 0.062 | 0.16 | - | - | - | 0.21 | 0.57 | - | - | - | - | |
xcell: T cell CD4+ Th1 | 0.063 | 0.31 | - | - | - | 0.36 | 0.2 | - | - | - | - | |
cibersort: NK cell activated | 0.068 | 0.23 | - | - | - | 0.34 | 0.31 | - | - | - | - | |
HALLMARK_E2F_TARGETS | 0.088 | 0.3 | - | - | - | -0.62 | 0.015 | - | - | - | - | |
HALLMARK_SPERMATOGENESIS | 0.094 | 0.38 | - | - | - | 0.94 | 0.051 | - | - | - | - | |
HALLMARK_DNA_REPAIR | 0.11 | 0.44 | - | - | - | -0.69 | 0.016 | - | - | - | - |
Cis-association
Associations between omics data of MUS81
Trans-association
Associations of the protein abundance of MUS81 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.