Gene: MYBPC3

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
myosin binding protein C3
Ensembl
ENSG00000134571.11
Summary
MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000545968.6 Primary ENSP00000442795.1 (0 phosphosite)
  • ENST00000399249.6
  • ENST00000256993.8
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.7e-7-0.011--9.5e-6-5.7e-17-2.5e-23--0.73-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0.511.522.533.544.555.566.577.5log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530354045500-5-10-15-20-25-30-35-40-45-50proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MYBPC3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: B cell naive-----------
cibersort: B cell memory-----------
HALLMARK_ANDROGEN_RESPONSE-----------
HALLMARK_UNFOLDED_PROTEIN_RESPONSE-----------
HALLMARK_PI3K_AKT_MTOR_SIGNALING-----------
HALLMARK_MTORC1_SIGNALING-----------
HALLMARK_E2F_TARGETS-----------
HALLMARK_MYC_TARGETS_V1-----------
HALLMARK_MYC_TARGETS_V2-----------
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MYBPC3

BRCA0.18proteinmRNASCNVmethylationCCRCC0.04proteinmRNASCNVmethylationCOAD0.05proteinmRNASCNVmethylationGBM-0.04proteinmRNASCNVmethylationHNSCC0.04proteinmRNASCNVmethylationLSCC0.17proteinmRNASCNVmethylationLUAD0.00proteinmRNASCNVmethylationOV0.14proteinmRNASCNVmethylationPDAC0.05proteinmRNASCNVmethylationUCEC0.01proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MYBPC3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.