Gene: MYO1F

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
myosin IF
Ensembl
ENSG00000142347.19
Summary
Myosins are molecular motors that use the energy from ATP hydrolysis to generate force on actin filaments. The protein encoded by this gene is an unconventional myosin that may be involved in the intracellular movement of membrane-enclosed compartments. There is evidence to suggest that mutations in this gene can result in hearing loss. [provided by RefSeq, Jan 2017]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-5.7e-10-4.6e-28--2.2e-5-2e-31-2.4e-29--6.5e-4-
protein2.4e-14-3.6e-274.5e-4-2.6e-15-2.7e-6-3.3e-5-0.381.8e-92.2e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC5678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC22.52323.52424.52525.52626.52727.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530354045500-5-10-15-20-25-30-35-40-45-50Pan-cancer0204060801001201401601802002202402602803000-20-40-60-80-100-120-140-160-180-200-220-240-260-280-300proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of MYO1F with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore1.5e-1482.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-16
HALLMARK_IL6_JAK_STAT3_SIGNALING3.4e-1422.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-161.5e-102.2e-16
HALLMARK_ALLOGRAFT_REJECTION3.1e-1412.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-162.2e-168.8e-102.2e-16
HALLMARK_INFLAMMATORY_RESPONSE3.7e-1412.2e-162.2e-162.2e-162.2e-162.2e-162.2e-161e-92.2e-162.2e-162.2e-16
HALLMARK_COMPLEMENT1.3e-1272.2e-162.2e-162.2e-162.2e-164.6e-162.2e-161.9e-82.2e-161.6e-62.2e-16
xcell: immune score5.2e-1262.2e-162.2e-162.2e-82.2e-162.2e-162.2e-162.1e-91e-102.2e-162.2e-16
ESTIMATE: ESTIMATEScore2.8e-1232.2e-162.2e-162e-92.2e-162.2e-162.2e-163e-82.2e-161.4e-82.2e-16
HALLMARK_IL2_STAT5_SIGNALING3.9e-1112.2e-163.4e-82.2e-162.2e-162.2e-162.2e-162.7e-82.2e-167.7e-61.6e-9
xcell: Macrophage5.0e-1111.2e-132.2e-165.2e-82.2e-161.2e-121.6e-154.4e-83.3e-82.2e-164.2e-13
HALLMARK_INTERFERON_GAMMA_RESPONSE2.0e-1022.2e-162.2e-162.6e-92.2e-162.2e-162.2e-162.1e-55e-82.3e-32.2e-16
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* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of MYO1F

BRCA0.670.01-0.02proteinmRNASCNVmethylationCCRCC0.830.100.05proteinmRNASCNVmethylationCOAD0.640.03-0.03proteinmRNASCNVmethylationGBM0.90-0.17-0.13proteinmRNASCNVmethylationHNSCC0.800.100.09proteinmRNASCNVmethylationLSCC0.850.120.06proteinmRNASCNVmethylationLUAD0.680.180.38proteinmRNASCNVmethylationOV0.66-0.27-0.19proteinmRNASCNVmethylationPDAC0.55-0.090.13proteinmRNASCNVmethylationUCEC0.78-0.09-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of MYO1F and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.