Basic information

Full name
NSFL1 cofactor
Ensembl
ENSG00000088833.17
Summary
N-ethylmaleimide-sensitive factor (NSF) and valosin-containing protein (p97) are two ATPases known to be involved in transport vesicle/target membrane fusion and fusions between membrane compartments. A trimer of the protein encoded by this gene binds a hexamer of cytosolic p97 and is required for p97-mediated regrowth of Golgi cisternae from mitotic Golgi fragments. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, May 2011]

Protein product

Phosphosites on the primary protein product
Loading...

Tumor and normal comparison

Loading, please wait
Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA2.3e-11-3.8e-10--0.0842.3e-70.6-0.21-
protein3.3e-4-1.3e-22-1.3e-6--0.380.34-5.3e-8-0.039-2.7e-7-0.34

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC99.51010.51111.51212.513log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.52929.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0.00.51.01.52.02.53.03.54.04.55.05.56.06.57.00.0-0.5-1.0-1.5-2.0-2.5-3.0-3.5-4.0-4.5-5.0-5.5-6.0-6.5-7.0Pan-cancer01234567890-1-2-3-4-5-6-7-8-9proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of NSFL1C with phenotypes and mutations

Loading, please wait
Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PBRM1 mutation4.3e-3-4.3e-3--------
xcell: T cell CD8+ naive0.0110.55-0.54-0.810.0610.017-0.29-0.460.426.2e-50.29
cibersort: Mast cell activated0.0311.5e-3-0.460.330.880.410.95-0.70.50.470.17
HALLMARK_PANCREAS_BETA_CELLS0.0420.710.420.960.095-0.082-0.910.230.230.490.022
HALLMARK_BILE_ACID_METABOLISM0.0444.1e-5-0.480.023-0.97-0.270.710.0520.058-0.27-0.21
chromosomal instability0.0450.86.5e-3-0.950.2-0.0170.052-0.330.760.230.04
HALLMARK_KRAS_SIGNALING_DN0.062-0.14-0.480.350.150.0580.160.589.1e-30.77-0.29
PATH-NP_PROLACTIN_PATHWAY0.07---0.490.061-----
KINASE-PSP_P38A/MAPK140.071---0.970.0391---0.13
SOX9 mutation0.08--0.08-------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of NSFL1C

BRCA0.330.530.56proteinmRNASCNVmethylationCCRCC0.43-0.180.23-0.300.38-0.20proteinmRNASCNVmethylationCOAD0.710.740.89proteinmRNASCNVmethylationGBM0.50-0.090.600.100.59-0.17proteinmRNASCNVmethylationHNSCC0.79-0.150.43-0.090.47-0.20proteinmRNASCNVmethylationLSCC0.77-0.240.57-0.080.67-0.07proteinmRNASCNVmethylationLUAD0.73-0.160.61-0.160.77-0.21proteinmRNASCNVmethylationOV0.640.640.68proteinmRNASCNVmethylationPDAC0.62-0.190.57-0.150.70-0.01proteinmRNASCNVmethylationUCEC0.58-0.230.32-0.050.30-0.19proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of NSFL1C and the protein abundance of other genes

Loading, please wait
Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.