Basic information
- Full name
- purinergic receptor P2Y2
- Ensembl
- ENSG00000175591.11
- Summary
- The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
- Annotation
- Druggable target (Tier T3)
Protein product
- ENST00000311131.6 Primary ENSP00000310305.2 (8 phosphosites)
- ENST00000393596.2
- ENST00000393597.6
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -0.49 | - | -1.9e-13 | - | - | -6.2e-14 | 7.6e-7 | 2.7e-3 | - | 7.4e-8 | - |
protein | 5.4e-3 | - | - | - | - | - | 2.2e-3 | 0.38 | - | - | - |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of P2RY2 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_ESTROGEN_RESPONSE_LATE | 1.3e-5 | 0.14 | - | - | - | 0.37 | 5.0e-5 | 0.16 | - | - | 0.052 | |
PROGENy: PI3K | 2.9e-5 | 0.53 | - | - | - | 0.052 | 0.023 | 0.008 | - | - | 0.066 | |
HALLMARK_ESTROGEN_RESPONSE_EARLY | 5.6e-5 | 0.044 | - | - | - | 0.6 | 2.8e-6 | -0.95 | - | - | 0.066 | |
PROGENy: EGFR | 8.9e-4 | -0.73 | - | - | - | 0.019 | 9.5e-4 | 0.43 | - | - | 0.18 | |
HALLMARK_GLYCOLYSIS | 0.001 | -0.89 | - | - | - | 0.27 | 4.5e-3 | 2.1e-3 | - | - | 0.65 | |
PROGENy: VEGF | 1.7e-3 | 0.81 | - | - | - | 0.012 | 4.6e-4 | 0.33 | - | - | -0.82 | |
HALLMARK_P53_PATHWAY | 4.4e-3 | -0.41 | - | - | - | 0.01 | 5.5e-4 | -0.86 | - | - | 0.17 | |
HALLMARK_CHOLESTEROL_HOMEOSTASIS | 5.3e-3 | 0.33 | - | - | - | 0.18 | 0.6 | 0.11 | - | - | 0.071 | |
cibersort: Myeloid dendritic cell activated | 5.5e-3 | 0.38 | - | - | - | 0.89 | 0.012 | 0.14 | - | - | 0.22 | |
HALLMARK_ANDROGEN_RESPONSE | 5.9e-3 | 0.038 | - | - | - | 0.18 | 0.19 | 0.68 | - | - | 0.3 |
Cis-association
Associations between omics data of P2RY2
Trans-association
Associations of the protein abundance of P2RY2 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.