Gene: P2RY2

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
purinergic receptor P2Y2
Ensembl
ENSG00000175591.11
Summary
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]
Annotation
Druggable target (Tier T3)

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.49--1.9e-13---6.2e-147.6e-72.7e-3-7.4e-8-
protein5.4e-3-----2.2e-30.38---

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCAHNSCCLSCCLUADUCEC13141516171819202122log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12Pan-cancer02468101214161820220-2-4-6-8-10-12-14-16-18-20-22proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of P2RY2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_ESTROGEN_RESPONSE_LATE1.3e-50.14---0.375.0e-50.16--0.052
PROGENy: PI3K2.9e-50.53---0.0520.0230.008--0.066
HALLMARK_ESTROGEN_RESPONSE_EARLY5.6e-50.044---0.62.8e-6-0.95--0.066
PROGENy: EGFR8.9e-4-0.73---0.0199.5e-40.43--0.18
HALLMARK_GLYCOLYSIS0.001-0.89---0.274.5e-32.1e-3--0.65
PROGENy: VEGF1.7e-30.81---0.0124.6e-40.33---0.82
HALLMARK_P53_PATHWAY4.4e-3-0.41---0.015.5e-4-0.86--0.17
HALLMARK_CHOLESTEROL_HOMEOSTASIS5.3e-30.33---0.180.60.11--0.071
cibersort: Myeloid dendritic cell activated5.5e-30.38---0.890.0120.14--0.22
HALLMARK_ANDROGEN_RESPONSE5.9e-30.038---0.180.190.68--0.3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of P2RY2

BRCA0.560.150.14proteinmRNASCNVmethylationCCRCC-0.150.070.02proteinmRNASCNVmethylationCOAD0.12proteinmRNASCNVmethylationGBM-0.21-0.080.11proteinmRNASCNVmethylationHNSCC0.840.15-0.23-0.170.55-0.25proteinmRNASCNVmethylationLSCC0.87-0.210.33-0.160.24-0.12proteinmRNASCNVmethylationLUAD0.70-0.120.21-0.330.37-0.41proteinmRNASCNVmethylationOV0.22proteinmRNASCNVmethylationPDAC-0.100.20-0.07proteinmRNASCNVmethylationUCEC0.75-0.190.56-0.240.25-0.19proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of P2RY2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.