Basic information
- Full name
- pantothenate kinase 4 (inactive)
- Ensembl
- ENSG00000157881.16
- Summary
- This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]
Protein product
- ENST00000378466.9 Primary ENSP00000367727.5 (11 phosphosites)
- ENST00000435556.8
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | -6.6e-8 | - | -2.4e-6 | - | - | -0.3 | -0.047 | -3.8e-3 | - | -0.15 | - |
protein | -1.6e-29 | - | -0.25 | -2.1e-28 | - | -2.1e-3 | -7.3e-18 | -8.2e-18 | -1.8e-3 | 2.8e-6 | -0.33 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of PANK4 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
xcell: stroma score | 3.2e-15 | 0.066 | 2.8e-3 | 1.5e-4 | -0.15 | 4.8e-5 | 8.4e-5 | 1.6e-3 | 0.62 | 1.1e-3 | 4.2e-3 | |
ESTIMATE: StromalScore | 9e-14 | 0.047 | -0.99 | 1.9e-8 | -6.0e-5 | 5.4e-6 | 8.5e-4 | 0.021 | 0.038 | 0.03 | 2.8e-8 | |
xcell: Cancer associated fibroblast | 9.8e-14 | 0.042 | 0.21 | 3.6e-4 | -0.52 | 5.7e-6 | 4.1e-4 | 1.1e-3 | 0.94 | 3.2e-3 | 0.003 | |
xcell: microenvironment score | 1e-13 | 2.4e-4 | -0.3 | 1.2e-6 | -5.9e-5 | 1.9e-6 | 2.8e-4 | 1.5e-3 | 0.49 | 1.9e-3 | 2.7e-6 | |
HALLMARK_UV_RESPONSE_DN | 1.1e-12 | 0.023 | 0.26 | 2.2e-5 | -0.078 | 6.9e-4 | 3.4e-4 | 0.005 | 0.043 | 0.21 | 3.4e-4 | |
ESTIMATE: ESTIMATEScore | 4.4e-11 | 0.011 | -0.12 | 3.4e-8 | -3.2e-5 | 6.6e-6 | 7.1e-5 | 0.018 | 0.14 | 0.12 | 4.1e-6 | |
xcell: Hematopoietic stem cell | 1.2e-10 | 9.7e-3 | 2.4e-3 | 0.015 | -0.5 | 4.4e-3 | 1.1e-3 | 1.6e-3 | 0.42 | -0.29 | 6.8e-5 | |
HALLMARK_MYOGENESIS | 2.9e-10 | 0.15 | 0.22 | 1.5e-4 | -0.032 | 6.9e-3 | 0.24 | 3.9e-6 | 0.18 | 0.24 | 3.3e-6 | |
HALLMARK_KRAS_SIGNALING_UP | 2.9e-9 | 0.17 | -0.77 | 1.1e-7 | -8.3e-3 | 9.5e-3 | 5.9e-4 | 0.11 | 0.038 | 0.043 | 8.9e-4 | |
HALLMARK_IL2_STAT5_SIGNALING | 6.6e-9 | 0.31 | -0.79 | 2e-8 | -8.2e-4 | 5.5e-4 | 3.4e-4 | 0.025 | 0.052 | 0.1 | 0.014 |
Cis-association
Associations between omics data of PANK4
Trans-association
Associations of the protein abundance of PANK4 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.