Basic information

Full name
plakophilin 1
Ensembl
ENSG00000081277.13
Summary
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This protein may be involved in molecular recruitment and stabilization during desmosome formation. Mutations in this gene have been associated with the ectodermal dysplasia/skin fragility syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.5e-16-1.2e-3--0.0911.3e-28-0.25-3.2e-4-
protein0.002-----0.481.6e-18-0.97-2.3e-52.4e-4-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC024681012141618log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1214161820222426283032log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PKP1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_KRAS_SIGNALING_DN2.4e-160.017-0.90.140.20.012.2e-160.0920.10.0112.0e-5
HALLMARK_P53_PATHWAY9.3e-80.11-0.99-0.51-0.642.7e-86.0e-40.410.50.0971.8e-5
PROGENy: p531.6e-6-0.11-0.36-0.90.792.4e-105.5e-100.660.640.0250.064
KINASE-PSP_P38A/MAPK142.2e-6---0.351.2e-90.85---0.023
HALLMARK_WNT_BETA_CATENIN_SIGNALING6.8e-57.2e-40.430.017-4.8e-3-0.0843.5e-6-0.950.260.0229.4e-3
chromosomal instability1.3e-40.0430.840.290.620.557.1e-6-0.930.480.950.012
KINASE-PSP_ERK2/MAPK11.3e-40.0230.67-0.53-0.319.5e-71.3e-30.610.860.580.093
HALLMARK_APICAL_SURFACE6.1e-4-0.350.450.72-0.780.0760.028-0.040.0324.0e-48.8e-4
PROGENy: PI3K7.2e-40.160.33-0.74-0.831.6e-80.020.95-0.30.180.6
cibersort: Macrophage M07.9e-40.120.140.018-0.830.80.040.590.880.220.23
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PKP1

BRCA0.78-0.07-0.09proteinmRNASCNVmethylationCCRCC0.90-0.75-0.08-0.290.120.11proteinmRNASCNVmethylationCOAD0.660.070.06proteinmRNASCNVmethylationGBM0.45-0.540.20-0.180.110.12proteinmRNASCNVmethylationHNSCC0.80-0.08-0.01-0.170.14-0.14proteinmRNASCNVmethylationLSCC0.94-0.360.28-0.400.33-0.18proteinmRNASCNVmethylationLUAD0.68-0.170.22-0.130.250.04proteinmRNASCNVmethylationOV0.330.050.19proteinmRNASCNVmethylationPDAC0.75-0.120.03-0.170.080.09proteinmRNASCNVmethylationUCEC0.67-0.090.21-0.050.220.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PKP1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.