Gene: PLAUR

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
plasminogen activator, urokinase receptor
Ensembl
ENSG00000011422.12
Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Annotation
Receptor

Protein product

  • ENST00000340093.8 Primary ENSP00000339328.3 (0 phosphosite)
  • ENST00000221264.8
  • ENST00000601723.5
  • ENST00000339082.7
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.9e-25-2.2e-18--1.7e-18-0.0110.011-7.1e-9-
protein1.6e-35-5.1e-70.02-5.4e-181.5e-81.7e-40.281.1e-150.51

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC4567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC18192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0510152025300-5-10-15-20-25-30Pan-cancer0204060801001201400-20-40-60-80-100-120-140proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PLAUR with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TNFa1.1e-476.3e-80.218.3e-62.2e-161.3e-94.5e-89e-90.0143.6e-50.007
HALLMARK_INFLAMMATORY_RESPONSE8.4e-431.6e-60.0112e-72.2e-161.1e-77.2e-91.9e-47.3e-34.6e-30.022
PROGENy: NFkB2.4e-424.7e-60.388.8e-62.2e-165.1e-93.9e-73.2e-80.0123.7e-40.013
HALLMARK_TNFA_SIGNALING_VIA_NFKB2.6e-416.6e-50.231.4e-52.2e-164.5e-101.2e-87.2e-61.7e-32.4e-40.11
HALLMARK_HYPOXIA4.4e-371.6e-50.576.8e-42.2e-162.4e-67.6e-71.8e-61.4e-32.3e-60.17
HALLMARK_IL6_JAK_STAT3_SIGNALING1.2e-313.8e-40.013.3e-52.2e-161.3e-41.4e-72.4e-40.0210.0710.1
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION1.7e-311.4e-30.0592.0e-42.2e-161.5e-51.9e-83.2e-54.5e-32.9e-4-0.5
PROGENy: Hypoxia2.3e-312.2e-8-0.871.7e-41.4e-42.2e-40.0572.5e-95.2e-32.2e-160.2
xcell: Monocyte7.8e-316.0e-40.0890.0012.1e-123.3e-56.2e-91.2e-50.221.3e-40.095
HALLMARK_GLYCOLYSIS4.6e-302.2e-160.0780.0352.5e-100.030.33.3e-50.0415.7e-90.017
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PLAUR

BRCA0.650.130.02proteinmRNASCNVmethylationCCRCC0.340.230.06proteinmRNASCNVmethylationCOAD0.560.160.19proteinmRNASCNVmethylationGBM0.80-0.18-0.17proteinmRNASCNVmethylationHNSCC0.63-0.060.10proteinmRNASCNVmethylationLSCC0.750.240.13proteinmRNASCNVmethylationLUAD0.690.210.28proteinmRNASCNVmethylationOV0.520.100.27proteinmRNASCNVmethylationPDAC0.610.150.19proteinmRNASCNVmethylationUCEC0.590.03-0.03proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PLAUR and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.