Basic information

Full name
protein phosphatase 2 regulatory subunit B'delta
Ensembl
ENSG00000112640.15
Summary
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA9.1e-12-8.2e-4--0.22.7e-101.3e-3-0.28-
protein0.51-4.2e-22-4.7e-16--0.680.96-0.19-0.99.4e-11-3.6e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC7.588.599.51010.51111.51212.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2121.52222.52323.52424.52525.52626.527log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer051015202530350-5-10-15-20-25-30-35proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PPP2R5D with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
Tumor Purity (ABSOLUTE)9e-100.250.130.511.9e-33.6e-59.5e-40.330.380.0110.25
Tumor Purity (WGS)3e-9-0.042-7.9e-32.8e-37.2e-4-0.84-6.2e-30.037
HALLMARK_SPERMATOGENESIS1.1e-87.2e-30.35-0.952.7e-80.0131.6e-40.710.026-0.20.17
KINASE-PSP_CDK53.7e-8---2.1e-76.6e-30.02--6.7e-4-0.19
chromosomal instability4.9e-61.9e-3-0.092-0.870.731.8e-49.3e-40.0740.218.7e-30.92
HALLMARK_G2M_CHECKPOINT1.7e-59.6e-4-0.94-0.730.920.0298.7e-70.290.36-0.430.021
HALLMARK_E2F_TARGETS3.3e-58.3e-40.63-0.094-0.960.0113.8e-60.150.3-0.390.025
xcell: T cell CD4+ Th13.5e-50.0580.13-0.610.0243.2e-30.0130.14-0.67-0.174.7e-3
KINASE-PSP_AMPKA1/PRKAA17.6e-4----0.14----7.1e-100.26
LMAN1 mutation8.7e-4---------8.7e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PPP2R5D

BRCA0.640.340.47proteinmRNASCNVmethylationCCRCC0.480.100.37-0.080.36-0.01proteinmRNASCNVmethylationCOAD0.160.130.48proteinmRNASCNVmethylationGBM0.50-0.020.300.040.220.06proteinmRNASCNVmethylationHNSCC0.560.170.510.180.590.32proteinmRNASCNVmethylationLSCC0.760.050.59-0.010.590.05proteinmRNASCNVmethylationLUAD0.660.040.610.080.770.18proteinmRNASCNVmethylationOV0.260.230.71proteinmRNASCNVmethylationPDAC0.380.160.27-0.170.51-0.14proteinmRNASCNVmethylationUCEC0.640.080.120.130.400.05proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PPP2R5D and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.