Basic information
- Full name
- protein phosphatase 4 catalytic subunit
- Ensembl
- ENSG00000149923.14
- Annotation
- Essential genes Phosphatase
Protein product
- ENST00000279387.12 Primary ENSP00000279387.7 (2 phosphosites)
- ENST00000561610.1
- ENST00000627746.2
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.2e-59 | - | 7.1e-16 | - | - | 0.011 | 1e-22 | 1.9e-30 | - | 6.3e-6 | - |
protein | 3.7e-35 | - | 2.9e-18 | 0.14 | - | 4.1e-5 | 4.7e-18 | 1.6e-9 | 0.24 | 0.079 | 2.2e-3 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of PPP4C with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CDK2 | 8.8e-28 | 6.3e-3 | 0.83 | 0.07 | 1.1e-5 | 3.1e-3 | 1.3e-5 | 1.6e-7 | 0.14 | 1.7e-3 | 2.2e-16 | |
KINASE-PSP_CDK1 | 2e-26 | 0.073 | -0.69 | 5.2e-3 | 1.2e-5 | 4.0e-5 | 4.1e-5 | 4.7e-8 | 0.033 | 5.0e-4 | 6.7e-9 | |
HALLMARK_G2M_CHECKPOINT | 7.1e-23 | 2.8e-4 | 0.76 | 0.062 | 1.1e-7 | 0.016 | 4.3e-5 | 2.0e-6 | 0.12 | 0.015 | 1.8e-6 | |
HALLMARK_E2F_TARGETS | 1.2e-22 | 2.2e-4 | 0.74 | 0.13 | 3.5e-8 | 0.032 | 5.9e-6 | 2.1e-6 | 0.074 | 0.049 | 2.1e-6 | |
HALLMARK_DNA_REPAIR | 3e-21 | 0.047 | 0.21 | 0.22 | 4.8e-6 | 8.8e-6 | 2.9e-7 | 6.4e-5 | 0.026 | 0.24 | 9.1e-5 | |
PERT-PSP_NOCODAZOLE | 2.8e-20 | 0.041 | 0.71 | 1.2e-3 | 0.012 | 1.4e-5 | 1.7e-4 | 1.0e-6 | 0.39 | 2.5e-3 | 3.5e-5 | |
HALLMARK_MYC_TARGETS_V2 | 6.1e-20 | 1.1e-3 | 0.85 | 0.52 | 2.9e-7 | 8.6e-6 | 2.6e-4 | 6.0e-5 | 0.13 | 0.18 | 2.5e-6 | |
xcell: T cell CD4+ Th1 | 6.7e-19 | 9.8e-4 | 0.036 | 0.098 | 1.4e-7 | 0.059 | 7.8e-5 | 5.5e-6 | 0.31 | 0.61 | 1.2e-4 | |
HALLMARK_MYC_TARGETS_V1 | 3.7e-15 | 2.3e-3 | 0.21 | 0.54 | 1.9e-4 | 2.6e-3 | 3.9e-6 | 0.003 | 0.051 | 0.29 | 8.8e-3 | |
PROGENy: PI3K | 7.4e-15 | 0.021 | 0.033 | 0.51 | 3.5e-4 | 1.4e-6 | 0.15 | 3.2e-3 | 0.093 | 3.5e-3 | 0.037 |
Cis-association
Associations between omics data of PPP4C
Trans-association
Associations of the protein abundance of PPP4C and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.