Basic information

Full name
protein kinase cGMP-dependent 1
Ensembl
ENSG00000185532.20
Summary
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity. [provided by RefSeq, Sep 2011]
Annotation
Druggable target (Tier T4) Protein Kinase

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-3.7e-24-0.78---0.06-5.4e-29-3.6e-33-0.036-
protein-4.4e-53--0.11-2.2e-26--6.5e-11-5.7e-35-4.8e-34-9.2e-72.9e-10-0.13

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC45678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2222.52323.52424.52525.52626.52727.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820222426280-2-4-6-8-10-12-14-16-18-20-22-24-26-28Pan-cancer01020304050607080901001101201301400-10-20-30-40-50-60-70-80-90-100-110-120-130-140proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PRKG1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: stroma score4.0e-1199.2e-112.2e-162.2e-165.6e-84.3e-82.2e-162.2e-162.2e-161.6e-112.2e-16
HALLMARK_MYOGENESIS1.6e-1122.2e-162.2e-162.2e-161.8e-56.3e-102.1e-152.2e-162.2e-162.8e-42.2e-16
HALLMARK_UV_RESPONSE_DN6.0e-1052.2e-162.2e-161.9e-63.6e-42.2e-162.2e-162.2e-162.2e-162.7e-32.2e-16
ESTIMATE: StromalScore1.3e-1042.2e-162.2e-165.6e-94e-72.2e-162.2e-169.7e-62.2e-163.9e-52.2e-16
PROGENy: TGFb6.1e-1012.2e-162.2e-169.6e-91.5e-42.2e-162.2e-162.1e-52.2e-161.0e-52.2e-16
xcell: Cancer associated fibroblast1.3e-894.6e-82e-146.6e-15-0.636.9e-71.6e-211.7e-151.8e-92.3e-112.9e-15
xcell: Hematopoietic stem cell4.9e-842.8e-112.2e-162.7e-81.9e-41.6e-42.2e-162.2e-167.3e-107.4e-44.7e-14
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION5.7e-742.2e-163.2e-81e-78.9e-42e-82.2e-160.0242.2e-167.7e-32.2e-16
HALLMARK_APICAL_JUNCTION3.2e-626.4e-94.6e-101.4e-36.1e-46.8e-88.8e-82.2e-42.2e-161.7e-32.2e-16
HALLMARK_TGF_BETA_SIGNALING3.6e-592.2e-163.1e-113.0e-60.0170.0322.2e-161.1e-72.3e-110.0212.1e-6
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PRKG1

BRCA0.73-0.16-0.10proteinmRNASCNVmethylationCCRCC0.87-0.00-0.08-0.04-0.06-0.10proteinmRNASCNVmethylationCOAD0.630.110.15proteinmRNASCNVmethylationGBM0.76-0.150.50-0.040.370.14proteinmRNASCNVmethylationHNSCC0.75-0.07-0.06-0.09-0.050.07proteinmRNASCNVmethylationLSCC0.720.180.000.060.130.06proteinmRNASCNVmethylationLUAD0.750.10-0.020.040.060.15proteinmRNASCNVmethylationOV0.840.04-0.04proteinmRNASCNVmethylationPDAC0.660.130.050.06-0.120.16proteinmRNASCNVmethylationUCEC0.86-0.070.13-0.070.080.28proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PRKG1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.