Basic information
- Full name
- protein arginine methyltransferase 7
- Ensembl
- ENSG00000132600.16
- Summary
- This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]
- Annotation
- Druggable target (Tier T3)
Protein product
- ENST00000339507.9 Primary ENSP00000343103.5 (1 phosphosite)
- ENST00000441236.2
- ENST00000449359.7
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 1.2e-4 | - | 1.6e-4 | - | - | -0.46 | 4.3e-3 | 4.7e-5 | - | -0.17 | - |
protein | 9.4e-7 | - | 4.7e-13 | - | - | 0.041 | 7.2e-8 | -1.1e-3 | - | -2.5e-3 | 2.8e-4 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of PRMT7 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
KINASE-PSP_CDK1 | 5.3e-8 | 0.37 | -0.58 | 0.32 | 0.19 | 2.1e-3 | 2.0e-5 | 1.4e-3 | 0.91 | 0.17 | 0.012 | |
HALLMARK_DNA_REPAIR | 5.0e-6 | 0.78 | 0.013 | 0.68 | 0.16 | 0.013 | 5.3e-5 | 0.46 | 0.8 | 0.55 | 0.08 | |
PERT-PSP_NOCODAZOLE | 5.9e-6 | 0.62 | -0.87 | 0.29 | 0.63 | 0.14 | 5.0e-4 | 3.4e-3 | 0.41 | 0.12 | 0.029 | |
HALLMARK_MYC_TARGETS_V2 | 7.3e-6 | -0.72 | 0.039 | 0.3 | 0.12 | 0.019 | 3.1e-3 | 0.13 | 0.71 | 0.35 | 0.079 | |
HALLMARK_GLYCOLYSIS | 9.9e-6 | 0.24 | 0.12 | 0.81 | 0.46 | 0.15 | 0.031 | 0.048 | 0.81 | 0.083 | 6.1e-3 | |
HALLMARK_MYC_TARGETS_V1 | 1.0e-5 | -0.73 | 0.13 | 0.7 | 0.39 | 4.1e-3 | 1.6e-4 | 0.19 | -0.69 | 0.12 | 0.016 | |
KINASE-PSP_CDK2 | 1.5e-5 | 0.26 | -0.46 | 0.93 | 0.03 | 0.015 | 0.014 | 0.018 | -0.84 | 0.15 | 0.01 | |
PROGENy: Hypoxia | 3.4e-5 | 0.42 | 2.1e-3 | 0.29 | 0.24 | 3.3e-3 | 0.82 | 9.6e-3 | -0.56 | -0.9 | 0.053 | |
HALLMARK_E2F_TARGETS | 9.1e-5 | 0.45 | 0.45 | 0.65 | 0.16 | 0.11 | 1.3e-3 | 0.23 | 0.24 | 0.65 | 0.16 | |
PATH-NP_TSLP_PATHWAY | 2.4e-4 | 0.13 | 0.22 | 0.18 | -0.64 | 0.011 | -0.93 | 0.56 | 0.032 | 0.12 | 0.2 |
Cis-association
Associations between omics data of PRMT7
Trans-association
Associations of the protein abundance of PRMT7 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.