Basic information

Full name
protein arginine methyltransferase 7
Ensembl
ENSG00000132600.16
Summary
This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]
Annotation
Druggable target (Tier T3)

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.2e-4-1.6e-4---0.464.3e-34.7e-5--0.17-
protein9.4e-7-4.7e-13--0.0417.2e-8-1.1e-3--2.5e-32.8e-4

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.511log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1717.51818.51919.52020.52121.52222.52323.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0.00.51.01.52.02.53.03.54.04.55.05.56.00.0-0.5-1.0-1.5-2.0-2.5-3.0-3.5-4.0-4.5-5.0-5.5-6.0Pan-cancer024681012140-2-4-6-8-10-12-14proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PRMT7 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK15.3e-80.37-0.580.320.192.1e-32.0e-51.4e-30.910.170.012
HALLMARK_DNA_REPAIR5.0e-60.780.0130.680.160.0135.3e-50.460.80.550.08
PERT-PSP_NOCODAZOLE5.9e-60.62-0.870.290.630.145.0e-43.4e-30.410.120.029
HALLMARK_MYC_TARGETS_V27.3e-6-0.720.0390.30.120.0193.1e-30.130.710.350.079
HALLMARK_GLYCOLYSIS9.9e-60.240.120.810.460.150.0310.0480.810.0836.1e-3
HALLMARK_MYC_TARGETS_V11.0e-5-0.730.130.70.394.1e-31.6e-40.19-0.690.120.016
KINASE-PSP_CDK21.5e-50.26-0.460.930.030.0150.0140.018-0.840.150.01
PROGENy: Hypoxia3.4e-50.422.1e-30.290.243.3e-30.829.6e-3-0.56-0.90.053
HALLMARK_E2F_TARGETS9.1e-50.450.450.650.160.111.3e-30.230.240.650.16
PATH-NP_TSLP_PATHWAY2.4e-40.130.220.18-0.640.011-0.930.560.0320.120.2
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PRMT7

BRCA0.270.220.41proteinmRNASCNVmethylationCCRCC0.380.010.01-0.130.33-0.08proteinmRNASCNVmethylationCOAD0.030.420.31proteinmRNASCNVmethylationGBM0.230.050.18-0.220.18-0.20proteinmRNASCNVmethylationHNSCC0.070.100.22-0.060.37-0.07proteinmRNASCNVmethylationLSCC0.53-0.030.31-0.150.60-0.14proteinmRNASCNVmethylationLUAD0.24-0.240.22-0.080.71-0.18proteinmRNASCNVmethylationOV0.230.070.67proteinmRNASCNVmethylationPDAC0.17-0.320.19-0.250.26-0.24proteinmRNASCNVmethylationUCEC0.26-0.060.24-0.080.43-0.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PRMT7 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.