Basic information

Full name
PTTG1 regulator of sister chromatid separation, securin
Ensembl
ENSG00000164611.13
Summary
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Annotation
Essential genes

Protein product

  • ENST00000352433.10 Primary ENSP00000344936.5 (0 phosphosite)
  • ENST00000393964.1
  • ENST00000520452.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA4.1e-98-4.4e-29--1.1e-83e-346.9e-32-8.2e-10-
protein5.5e-15-----5.5e-15----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCAHNSCCLSCCOVUCEC151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC05101520253035400-5-10-15-20-25-30-35-40Pan-cancer0204060801001201401601800-20-40-60-80-100-120-140-160-180proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of PTTG1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
KINASE-PSP_CDK12.2e-51.6e-3---0.020.06----
HALLMARK_SPERMATOGENESIS2.5e-50.021---0.0442.9e-3----
KINASE-PSP_CDK23.0e-50.003---0.0470.022----
PERT-PSP_NOCODAZOLE1.3e-40.036---0.0974.2e-3----
HALLMARK_G2M_CHECKPOINT1.5e-40.013---0.312.4e-3----
HALLMARK_E2F_TARGETS3.3e-40.018---0.190.011----
KINASE-PSP_ERK2/MAPK11.4e-39.4e-3---0.230.086----
chromosomal instability1.8e-30.017---0.460.022----
HALLMARK_MITOTIC_SPINDLE2.6e-30.046---0.150.073----
mutation burden4.1e-32.5e-3---0.320.34----
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of PTTG1

BRCA0.470.00-0.27proteinmRNASCNVmethylationCCRCC-0.260.33-0.28proteinmRNASCNVmethylationCOAD0.24proteinmRNASCNVmethylationGBM-0.020.15-0.07proteinmRNASCNVmethylationHNSCC0.200.37-0.11-0.130.41-0.17proteinmRNASCNVmethylationLSCC0.540.200.09-0.070.13-0.11proteinmRNASCNVmethylationLUAD0.110.17-0.07proteinmRNASCNVmethylationOV0.29proteinmRNASCNVmethylationPDAC0.090.31-0.02proteinmRNASCNVmethylationUCEC0.01-0.14-0.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of PTTG1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.