Basic information

Full name
S100 calcium binding protein A13
Ensembl
ENSG00000189171.14
Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Protein product

Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.063-2.5e-16---3.7e-4-2.4e-141.8e-9-0.26-
protein-6.3e-4-6.1e-15-2.7e-22--2.7e-5-4e-262.2e-87.1e-40.003-7.5e-7

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC25.52626.52727.52828.52929.53030.53131.53232.5log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0246810121416182022240-2-4-6-8-10-12-14-16-18-20-22-24proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of S100A13 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_MYOGENESIS8.5e-180.02-0.620.0152.5e-32.2e-161.0e-42.2e-3-0.930.157.3e-4
HALLMARK_COAGULATION1.3e-130.30.140.119.3e-43.6e-55.2e-90.920.06-0.781.7e-5
KINASE-PSP_PKACA/PRKACA1.6e-130.13-0.744.8e-41.2e-43.9e-55.3e-61.4e-8-0.740.820.57
HALLMARK_HEME_METABOLISM3e-120.0640.54.3e-39.6e-40.054.6e-51.9e-30.031-0.578.3e-3
xcell: Hematopoietic stem cell9.1e-100.1-0.420.0330.0340.021.4e-69.6e-4-0.333.5e-40.22
HALLMARK_APICAL_JUNCTION1.7e-90.490.820.460.012e-81.5e-30.0290.91-0.971.6e-4
cibersort: Mast cell activated1.8e-80.0260.650.25-0.240.0150.336.3e-70.392.3e-40.028
HALLMARK_KRAS_SIGNALING_UP3.6e-8-0.15-0.470.0170.0291.5e-38e-8-0.940.450.0511.3e-4
xcell: stroma score1.1e-70.057-0.285.0e-40.512.0e-46.6e-50.016-0.0770.0480.13
HALLMARK_UV_RESPONSE_DN1.8e-70.013-0.150.0941.7e-31.4e-31.2e-40.37-0.650.0570.19
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of S100A13

BRCA0.740.210.31proteinmRNASCNVmethylationCCRCC0.680.03-0.04proteinmRNASCNVmethylationCOAD0.660.210.11proteinmRNASCNVmethylationGBM0.84-0.12-0.05proteinmRNASCNVmethylationHNSCC0.760.120.07proteinmRNASCNVmethylationLSCC0.85-0.06-0.15proteinmRNASCNVmethylationLUAD0.690.230.23proteinmRNASCNVmethylationOV0.690.270.27proteinmRNASCNVmethylationPDAC0.610.160.17proteinmRNASCNVmethylationUCEC0.850.330.25proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of S100A13 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.