Basic information
- Full name
- spliceosome associated factor 3, U4/U6 recycling protein
- Ensembl
- ENSG00000075856.12
- Summary
- The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing. [provided by RefSeq, Jul 2008]
- Annotation
- Essential genes
Protein product
- ENST00000546815.6 Primary ENSP00000449386.2 (10 phosphosites)
- ENST00000228284.8
- ENST00000431469.6
- ENST00000546611.1
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 3.8e-40 | - | 3.4e-23 | - | - | 4.1e-7 | 9.8e-26 | 0.017 | - | 0.074 | - |
protein | 5.4e-52 | - | 1.2e-18 | 2.5e-27 | - | 1.2e-5 | 1.6e-25 | 7.2e-17 | 3.9e-6 | -2.1e-4 | -0.42 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SART3 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
chromosomal instability | 3.7e-28 | 0.087 | 2.5e-3 | 1.5e-7 | 1.5e-7 | 5.4e-4 | 2.2e-16 | 0.094 | 0.011 | 0.021 | 0.17 | |
Tumor Purity (ABSOLUTE) | 5.8e-17 | 0.22 | 0.094 | 2.9e-4 | 2.2e-8 | 0.037 | 3.2e-10 | -0.86 | 5.6e-3 | 0.026 | 0.25 | |
Tumor Purity (WGS) | 4.7e-15 | - | 0.056 | - | 3.7e-11 | 0.011 | 6.1e-12 | 0.35 | - | 0.58 | 0.2 | |
HALLMARK_MYC_TARGETS_V2 | 2.9e-7 | 0.55 | 0.61 | 0.74 | 5.9e-4 | -0.94 | 1.2e-9 | 0.063 | 1.5e-4 | -0.67 | 0.9 | |
HALLMARK_SPERMATOGENESIS | 3.5e-7 | 0.59 | 0.92 | -0.05 | 0.011 | 1.3e-4 | 2.9e-9 | 0.09 | 0.046 | 0.16 | 0.97 | |
xcell: T cell CD4+ Th1 | 1.6e-6 | 3.9e-3 | -0.53 | 0.14 | 9.7e-8 | 0.6 | 1.2e-4 | 0.18 | 0.029 | -0.099 | -0.9 | |
SBS4 (smoking) | 6.4e-6 | - | - | - | - | 6.6e-3 | 0.031 | 3.2e-3 | - | - | - | |
KINASE-PSP_CK2A1/CSNK2A1 | 1.1e-5 | 0.82 | 0.47 | -0.98 | 7.3e-3 | 0.045 | 0.013 | 0.01 | 0.99 | 0.36 | 0.019 | |
HALLMARK_E2F_TARGETS | 1.1e-5 | 0.89 | 0.17 | -0.27 | 1.1e-5 | 5.3e-3 | 7e-9 | 0.17 | -0.8 | -0.23 | 0.53 | |
xcell: Common lymphoid progenitor | 1.2e-5 | 0.029 | 0.094 | 0.07 | -0.057 | 0.39 | 2.4e-4 | 8.5e-3 | 0.19 | 0.33 | 0.54 |
Cis-association
Associations between omics data of SART3
Trans-association
Associations of the protein abundance of SART3 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
No matching records found |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.