Basic information

Full name
serpin family E member 2
Ensembl
ENSG00000135919.13
Summary
This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Annotation
Druggable target (Tier T4) Ligand

Protein product

  • ENST00000258405.9 Primary ENSP00000258405.4 (0 phosphosite)
  • ENST00000447280.6
  • ENST00000409840.7
  • ENST00000409304.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA1.8e-26-0.077--8e-95.4e-273.3e-14--0.038-
protein0.018--9.2e-152.8e-4-0.81.3e-13-0.92-0.0181.6e-30.015

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC456789101112131415log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC181920212223242526272829log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214160-2-4-6-8-10-12-14-16Pan-cancer0246810121416182022242628300-2-4-6-8-10-12-14-16-18-20-22-24-26-28-30proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SERPINE2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: TGFb6.9e-201.3e-81.4e-42.0e-40.980.0026.6e-44.1e-30.992.5e-31.2e-3
HALLMARK_MYOGENESIS8.6e-192e-102.0e-53.9e-4-0.930.050.0350.0840.874.0e-68.3e-4
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION1.1e-183e-72.2e-162.7e-4-0.142.7e-45.2e-30.024-0.790.0410.052
xcell: stroma score1.3e-175.6e-70.0197.5e-50.0190.350.790.0480.254.2e-91.5e-3
xcell: Cancer associated fibroblast4.5e-153.7e-56.1e-76.1e-5-0.180.320.460.0920.181.4e-66.1e-4
HALLMARK_HEDGEHOG_SIGNALING5.4e-145.9e-57.6e-30.0111.9e-30.0530.0470.27-0.962.4e-35.3e-4
ESTIMATE: StromalScore6.6e-141.6e-73.3e-62.4e-4-0.230.0170.120.0470.722.4e-40.17
HALLMARK_UV_RESPONSE_DN8e-145e-98.4e-63.3e-3-0.896.5e-40.460.51-0.966.9e-32.3e-3
xcell: Hematopoietic stem cell7.7e-112.2e-90.415.8e-4-0.750.13-0.860.140.084.9e-49.7e-3
HALLMARK_TGF_BETA_SIGNALING1.9e-105.5e-82.8e-34.7e-4-0.50.0660.090.230.480.110.063
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SERPINE2

BRCA0.740.210.36proteinmRNASCNVmethylationCCRCC0.72-0.060.23-0.090.24-0.09proteinmRNASCNVmethylationCOAD0.730.110.12proteinmRNASCNVmethylationGBM0.77-0.180.31-0.090.19-0.15proteinmRNASCNVmethylationHNSCC0.770.050.01-0.010.04-0.11proteinmRNASCNVmethylationLSCC0.74-0.040.15-0.210.23-0.06proteinmRNASCNVmethylationLUAD0.77-0.160.02-0.200.01-0.06proteinmRNASCNVmethylationOV0.690.100.08proteinmRNASCNVmethylationPDAC0.69-0.120.120.010.04-0.22proteinmRNASCNVmethylationUCEC0.84-0.06-0.10-0.100.00-0.04proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SERPINE2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.