Gene: SIRPA

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
signal regulatory protein alpha
Ensembl
ENSG00000198053.11
Summary
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Annotation
Receptor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA0.16-2.9e-28--2.1e-14-2.5e-18-4.8e-20--5.6e-3-
protein-1.2e-5-7.9e-30-2.2e-5-1e-13-5e-13-2.3e-23-0.02-0.17-3.7e-3

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC77.588.599.51010.51111.51212.51313.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC1819202122232425262728log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC02468101214161820220-2-4-6-8-10-12-14-16-18-20-22Pan-cancer010203040506070800-10-20-30-40-50-60-70-80proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SIRPA with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
HALLMARK_INFLAMMATORY_RESPONSE1.2e-331.3e-90.173.1e-3-3.5e-31.1e-72.2e-162.1e-60.0024.6e-43.2e-9
HALLMARK_IL6_JAK_STAT3_SIGNALING1.6e-309.4e-80.320.004-2.5e-41.1e-52.2e-161.2e-72.2e-34.7e-43e-10
HALLMARK_COMPLEMENT2e-299.2e-80.241.4e-3-4.3e-38.1e-52.2e-169.1e-62.6e-31.7e-31.6e-9
ESTIMATE: ImmuneScore1.2e-285.4e-70.972.2e-4-0.0154.5e-42.2e-168.7e-72.2e-34.0e-42.9e-8
ESTIMATE: ESTIMATEScore4.3e-266.4e-60.418.1e-5-0.0227.3e-52.2e-161.6e-41.3e-31.6e-34.0e-5
HALLMARK_ALLOGRAFT_REJECTION5e-243.7e-70.814.3e-3-1.2e-31.6e-42.2e-164.9e-68.2e-30.0047.3e-7
xcell: Monocyte7.6e-242.4e-40.176.9e-3-0.0298.3e-63.7e-122.1e-69.1e-31.5e-42.0e-4
PROGENy: TNFa9.2e-231.2e-70.140.034-0.0034.2e-84.1e-86.3e-40.0331.6e-35.2e-8
xcell: Macrophage5.9e-221.3e-60.237.6e-3-0.0363.8e-34.1e-101.7e-40.0111.8e-43.2e-6
PROGENy: NFkB4.6e-211.8e-70.50.027-3.9e-32.1e-65.1e-81.9e-40.0521.1e-35.1e-8
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SIRPA

BRCA0.56-0.07-0.03proteinmRNASCNVmethylationCCRCC0.43-0.080.17-0.130.09-0.08proteinmRNASCNVmethylationCOAD0.37-0.020.14proteinmRNASCNVmethylationGBM0.44-0.260.31-0.170.40-0.15proteinmRNASCNVmethylationHNSCC0.73-0.060.240.020.24-0.10proteinmRNASCNVmethylationLSCC0.820.080.090.090.13-0.19proteinmRNASCNVmethylationLUAD0.39-0.04-0.050.15-0.09-0.17proteinmRNASCNVmethylationOV0.540.00-0.07proteinmRNASCNVmethylationPDAC0.440.010.17-0.140.210.16proteinmRNASCNVmethylationUCEC0.680.070.150.060.07-0.19proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SIRPA and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.