Gene: SLC25A14

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
solute carrier family 25 member 14
Ensembl
ENSG00000102078.16
Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). Uncoupling proteins separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. Uncoupling proteins facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on chromosome 4. [provided by RefSeq, Aug 2013]

Protein product

  • ENST00000545805.6 Primary ENSP00000444642.2 (0 phosphosite)
  • ENST00000218197.9
  • ENST00000612248.4
  • ENST00000339231.3
  • ENST00000361980.9
  • ENST00000543953.5
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA3.2e-16-2e-8--0.22.6e-111.7e-8--0.35-
protein0.14------0.682.4e-5-0.21--

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC66.577.588.599.51010.5log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMLSCCLUADOVUCEC161718192021222324252627log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456780-1-2-3-4-5-6-7-8Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SLC25A14 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
cibersort: Myeloid dendritic cell activated5.4e-40.58--0.26-0.920.024-0.95-6.8e-6
Clinical: Tumor_Size_cm1.7e-3---0.36-0.191.3e-3--0.41
DISEASE-PSP_Alzheimer's_disease6.2e-3---2.7e-4-----0.82
RB1 mutation7.9e-3---7.9e-3------
HALLMARK_SPERMATOGENESIS8.7e-30.86--1.9e-3-0.590.370.49-0.3
Tumor Purity (WGS)0.04---0.51-19.6e-3--0.39
Clinical: Path_Stage_pT0.0630.16----0.562.9e-3---0.22
ATRX mutation0.085---0.085------
cibersort: Neutrophil0.180.52---0.1-0.62-0.540.092-6.4e-3
PROGENy: Estrogen0.180.69--0.29--0.390.360.68-0.17
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SLC25A14

BRCA0.320.120.34proteinmRNASCNVmethylationCCRCC-0.230.17-0.18proteinmRNASCNVmethylationCOAD0.53proteinmRNASCNVmethylationGBM0.29-0.150.13-0.230.360.00proteinmRNASCNVmethylationHNSCC-0.150.28-0.45proteinmRNASCNVmethylationLSCC0.38-0.07-0.01-0.300.47-0.54proteinmRNASCNVmethylationLUAD0.35-0.070.240.090.59-0.27proteinmRNASCNVmethylationOV0.220.030.14proteinmRNASCNVmethylationPDAC-0.170.24-0.50proteinmRNASCNVmethylationUCEC0.17-0.12-0.080.010.200.29proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SLC25A14 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.