Basic information

Full name
solute carrier family 25 member 3
Ensembl
ENSG00000075415.13
Summary
The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated. [provided by RefSeq, Jul 2008]
Annotation
Essential genes

Protein product

  • ENST00000228318.7 Primary ENSP00000228318.3 (4 phosphosites)
  • ENST00000551917.5
  • ENST00000401722.7
  • ENST00000552981.6
  • ENST00000188376.9
  • ENST00000549338.5
  • ENST00000548847.1
  • ENST00000547534.5
  • ENST00000551265.5
Phosphosites on the primary protein product
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Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.1e-16--6e-22---9.1e-176.6e-3-0.57--6.2e-3-
protein0.012--2.9e-196.7e-4--9e-109.9e-95.2e-144.7e-40.220.96

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC11.81212.212.412.612.81313.213.413.613.81414.214.414.614.8log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2525.52626.52727.52828.52929.53030.531log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789101112130-1-2-3-4-5-6-7-8-9-10-11-12-13Pan-cancer0510152025303540455055600-5-10-15-20-25-30-35-40-45-50-55-60proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SLC25A3 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
chromosomal instability3.9e-120.031.5e-42.2e-40.052-0.589.3e-81.1e-38.7e-3-0.330.52
HALLMARK_OXIDATIVE_PHOSPHORYLATION1e-8-0.742.4e-3-0.140.630.259.5e-33.5e-49.5e-79.2e-40.41
Tumor Purity (WGS)8e-8--0.57-0.0970.351.1e-60.022-0.182.4e-4
HALLMARK_PEROXISOME5.4e-70.0249.7e-40.160.310.270.27-0.926.5e-30.240.059
Tumor Purity (ABSOLUTE)5.9e-7-0.35-0.637.9e-50.230.531.6e-40.173.7e-4-0.621.2e-3
cibersort: T cell regulatory (Tregs)1.2e-60.698.4e-30.054-0.730.0960.0110.026-0.143.3e-40.026
HALLMARK_MYC_TARGETS_V22.2e-60.314.2e-3-0.59-0.051-0.794.5e-56.4e-49.6e-60.0770.87
xcell: T cell CD4+ Th19.3e-60.11-0.0210.560.150.511.1e-31.5e-40.180.0370.12
HALLMARK_BILE_ACID_METABOLISM2.1e-40.0249.6e-30.240.170.085-0.11-0.50.040.0740.29
HALLMARK_KRAS_SIGNALING_DN4.9e-40.460.980.0282.6e-80.185.9e-3-0.120.52-0.68-0.77
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SLC25A3

BRCA0.330.190.34proteinmRNASCNVmethylationCCRCC0.49-0.190.35-0.040.47-0.06proteinmRNASCNVmethylationCOAD0.060.230.36proteinmRNASCNVmethylationGBM0.070.02-0.160.110.270.12proteinmRNASCNVmethylationHNSCC0.23-0.100.07-0.040.26-0.00proteinmRNASCNVmethylationLSCC0.48-0.330.46-0.200.41-0.28proteinmRNASCNVmethylationLUAD0.55-0.040.53-0.210.67-0.15proteinmRNASCNVmethylationOV0.610.380.55proteinmRNASCNVmethylationPDAC0.46-0.090.22-0.350.53-0.12proteinmRNASCNVmethylationUCEC0.060.120.02-0.120.27-0.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SLC25A3 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.