Gene: SLC27A5

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
solute carrier family 27 member 5
Ensembl
ENSG00000083807.10
Summary
The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

Protein product

  • ENST00000263093.7 Primary ENSP00000263093.2 (0 phosphosite)
  • ENST00000601355.1
  • ENST00000594786.1
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.2e-4--3.8e-26---2.8e-51.1e-92.2e-3--2.6e-3-
protein-----------

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC2345678910log2(RSEM+1)tumornormal
Protein expression

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC01234567890-1-2-3-4-5-6-7-8-9Pan-cancer02468101214160-2-4-6-8-10-12-14-16proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of SLC27A5 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: Common lymphoid progenitor-----------
xcell: Common myeloid progenitor-----------
xcell: Myeloid dendritic cell-----------
xcell: Endothelial cell-----------
xcell: Eosinophil-----------
xcell: Cancer associated fibroblast-----------
xcell: Granulocyte-monocyte progenitor-----------
xcell: Hematopoietic stem cell-----------
xcell: Macrophage-----------
xcell: Macrophage M1-----------
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of SLC27A5

BRCA0.26proteinmRNASCNVmethylationCCRCC-0.110.08-0.08proteinmRNASCNVmethylationCOAD0.14proteinmRNASCNVmethylationGBM-0.050.38-0.01proteinmRNASCNVmethylationHNSCC-0.240.150.00proteinmRNASCNVmethylationLSCC0.020.320.14proteinmRNASCNVmethylationLUAD-0.260.25-0.03proteinmRNASCNVmethylationOV0.43proteinmRNASCNVmethylationPDAC-0.200.21-0.04proteinmRNASCNVmethylationUCEC-0.170.220.10proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of SLC27A5 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.