Basic information
- Full name
- solute carrier family 7 member 5
- Ensembl
- ENSG00000103257.9
- Annotation
- Essential genes Druggable target (Tier T3)
Protein product
- ENST00000261622.5 Primary ENSP00000261622.4 (3 phosphosites)
- ENST00000565644.5
Phosphosites on the primary protein product
Tumor and normal comparison
Signed p-values | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Data type | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC |
RNA | 4e-52 | - | 0.049 | - | - | 4.6e-11 | 1.3e-31 | 4.6e-28 | - | 6.3e-3 | - |
protein | 3.3e-65 | - | 0.05 | 1e-22 | - | 4.5e-9 | 1.9e-31 | 1e-24 | 0.018 | 0.23 | 3.5e-7 |
mRNA expression at gene level
Protein expression
Phenotype and mutation association
Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types
Associations of the protein abundance of SLC7A5 with phenotypes and mutations
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Phenotype | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
HALLMARK_MTORC1_SIGNALING | 6.1e-21 | 2.2e-8 | 1.0e-6 | 0.004 | -0.6 | 0.086 | 1.1e-5 | 3.6e-5 | 0.017 | 0.051 | 0.023 | |
HALLMARK_UNFOLDED_PROTEIN_RESPONSE | 1.6e-16 | 8.1e-8 | 1.3e-5 | 0.24 | -0.57 | 9.7e-5 | 0.024 | 5.6e-7 | 0.27 | 0.053 | 0.12 | |
KINASE-PSP_CDK1 | 2.3e-15 | 3.9e-8 | 4.8e-4 | 4.2e-3 | -0.15 | 0.034 | 1.9e-6 | 1.5e-7 | 0.86 | 0.1 | 0.49 | |
PROGENy: PI3K | 2.7e-15 | 4.7e-3 | 4.5e-3 | 0.23 | -0.25 | 1.8e-9 | 0.095 | 6.8e-4 | 0.012 | 0.018 | 0.001 | |
KINASE-PSP_CDK2 | 3.8e-15 | 2.2e-16 | 2.0e-4 | 0.2 | -0.9 | 0.36 | 2.8e-4 | 2.3e-10 | -0.71 | 0.4 | 0.67 | |
HALLMARK_MYC_TARGETS_V2 | 4e-15 | 3.2e-7 | 4.2e-7 | 0.031 | -0.19 | 8.8e-3 | 2.2e-5 | 2.7e-8 | 0.91 | 0.41 | 0.66 | |
HALLMARK_G2M_CHECKPOINT | 1.7e-14 | 2.2e-8 | 4.6e-6 | 5.6e-3 | -0.7 | 0.74 | 3.5e-4 | 2e-8 | 0.14 | 0.61 | 0.85 | |
KINASE-PSP_ERK2/MAPK1 | 9.1e-13 | 1.5e-7 | 2.1e-3 | -0.71 | 0.098 | 0.013 | 2.6e-4 | 9.1e-4 | 0.16 | 0.81 | 0.058 | |
HALLMARK_E2F_TARGETS | 8.4e-12 | 4.1e-8 | 7.8e-6 | 0.064 | -0.6 | -0.6 | 0.003 | 1.2e-8 | 0.34 | 0.48 | 0.62 | |
HALLMARK_SPERMATOGENESIS | 2e-11 | 6.1e-6 | 0.011 | 0.096 | 7.9e-3 | -0.29 | 3.2e-3 | 2.4e-6 | 0.17 | 0.77 | 0.12 |
Cis-association
Associations between omics data of SLC7A5
Trans-association
Associations of the protein abundance of SLC7A5 and the protein abundance of other genes
Signed p-values | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene | Meta P | BRCA | CCRCC | COAD | GBM | HNSCC | LSCC | LUAD | OV | PDAC | UCEC | |
SLC3A2 | 4.3e-121 | 2.2e-16 | 2.2e-5 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 2.2e-16 | 4.3e-5 | 2.2e-16 | |
SLC7A1 | 1e-36 | 2.2e-16 | 0.086 | 0.14 | 0.029 | 4.1e-9 | 1.9e-8 | 2.2e-16 | 0.04 | 0.24 | 4.6e-4 | |
SLC1A5 | 4e-36 | 6.2e-6 | 3.4e-6 | 1.1e-3 | -0.25 | 0.019 | 5.7e-9 | 2.2e-16 | 0.004 | 0.35 | 2.2e-16 | |
BSG | 7.4e-35 | 2.2e-6 | 3.1e-9 | 1.3e-3 | 0.039 | 1.5e-6 | 3.0e-5 | 4.8e-3 | 2.7e-3 | 0.011 | 1.7e-8 | |
MTHFD1L | 9.8e-31 | 3e-7 | 1.3e-9 | 0.015 | 1.6e-3 | 5.8e-3 | 1.3e-3 | 4.8e-10 | 0.042 | 0.063 | 3.6e-4 | |
SELENOI | 5.4e-28 | 4.4e-3 | 5.6e-4 | 0.032 | 5.3e-3 | 0.85 | 3.2e-6 | 2.2e-16 | - | 0.69 | 2.2e-16 | |
RAB10 | 4.5e-26 | 1.5e-4 | 6.5e-4 | 0.58 | 8.5e-5 | 3.0e-5 | 1.0e-5 | 2.7e-4 | 0.24 | 0.014 | 4.7e-9 | |
ATP1B3 | 7.7e-26 | 2.2e-16 | 4.0e-4 | -0.77 | 0.78 | 8.9e-4 | 4.8e-7 | 1.7e-6 | 0.04 | 0.051 | 1.3e-5 | |
NOP2 | 1.6e-25 | 2.3e-10 | 2.2e-16 | 0.016 | -1.4e-3 | 0.089 | 4.4e-6 | 2.2e-16 | 0.12 | 0.082 | 0.15 | |
SLC38A2 | 7e-25 | 4.3e-5 | 7.6e-3 | 0.03 | 4.6e-3 | 2.1e-8 | 1.9e-3 | 1.7e-7 | 0.99 | 4.6e-4 | 8.2e-4 |
Gene set enrichment analysis
Submit genes and the common logarithm of the p-values of their association with to WebGestalt.