Gene: ST6GALNAC2

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Basic information

Full name
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Ensembl
ENSG00000070731.11
Summary
ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein targeting (Samyn-Petit et al., 2000 [PubMed 10742600]).[supplied by OMIM, Mar 2008]

Protein product

  • ENST00000225276.10 Primary ENSP00000225276.4 (0 phosphosite)
Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-1.7e-12--2.5e-26--1.1e-61.6e-9-4.2e-33--4.4e-5-
protein-0.83------0.83----

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC234567891011121314log2(RSEM+1)tumornormal
Protein expression
BRCAHNSCCLSCCLUADOVUCEC131415161718192021log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC0123456789100-1-2-3-4-5-6-7-8-9-10Pan-cancer01234567891011120-1-2-3-4-5-6-7-8-9-10-11-12proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of ST6GALNAC2 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
PROGENy: p533.2e-50.028----1.8e-3---0.059
HALLMARK_FATTY_ACID_METABOLISM9.7e-40.16----1.5e-3---0.26
PROGENy: Androgen1.8e-30.4----0.027---0.018
HALLMARK_XENOBIOTIC_METABOLISM2.8e-30.05----0.071---0.16
HALLMARK_ESTROGEN_RESPONSE_LATE9.6e-30.18----0.19---0.067
ARID1A mutation0.014---------0.014
HALLMARK_GLYCOLYSIS0.0160.34----0.46---0.013
PROGENy: Hypoxia0.0160.5----0.31---0.013
HALLMARK_PEROXISOME0.0260.37----0.07---0.25
cibersort: Neutrophil0.0280.41-----0.9---1.9e-3
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of ST6GALNAC2

BRCA0.540.260.27proteinmRNASCNVmethylationCCRCC0.130.140.12proteinmRNASCNVmethylationCOAD-0.04proteinmRNASCNVmethylationGBM0.16-0.17-0.24proteinmRNASCNVmethylationHNSCC-0.100.33-0.06proteinmRNASCNVmethylationLSCC0.520.250.20-0.070.40-0.11proteinmRNASCNVmethylationLUAD0.010.360.23proteinmRNASCNVmethylationOV0.31proteinmRNASCNVmethylationPDAC0.000.25-0.03proteinmRNASCNVmethylationUCEC0.650.52-0.090.09-0.200.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of ST6GALNAC2 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.