Gene: STAP1

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
signal transducing adaptor family member 1
Ensembl
ENSG00000035720.8
Summary
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-5.3e-3--2.3e-28--5.8e-3-7.6e-30.66-0.15-
protein-4.4e-3--2.1e-4---9.6e-4-0.380.059--0.71-

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC012345678910111213log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCHNSCCLSCCLUADOVPDAC161718192021222324log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer01020304050607080901000-10-20-30-40-50-60-70-80-90-100proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of STAP1 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
xcell: B cell1.2e-288.5e-60.36--1.3e-62.1e-234.5e-5-3.1e-3-
HALLMARK_ALLOGRAFT_REJECTION1e-223.2e-60.008--2.1e-52.2e-160.047-0.023-
xcell: immune score4.3e-222.0e-40.046--1.2e-62.2e-169.9e-4-0.11-
ESTIMATE: ImmuneScore1.6e-216.1e-50.017--6.7e-62.2e-160.027-0.043-
xcell: microenvironment score2.1e-214.7e-50.042--1.5e-62.2e-166.6e-3-0.15-
HALLMARK_IL6_JAK_STAT3_SIGNALING2.7e-212.4e-54.1e-3--2.3e-42.2e-160.12-7.9e-3-
HALLMARK_IL2_STAT5_SIGNALING1.5e-193.2e-40.041--2.5e-52.2e-160.32-0.002-
xcell: B cell plasma3e-197.5e-40.89--2.1e-52.2e-163.5e-4-0.015-
xcell: T cell CD8+ central memory6.9e-193.4e-50.27--4.5e-53e-116.6e-3-2.2e-3-
HALLMARK_COMPLEMENT2.4e-181.2e-40.013--5.7e-42.2e-160.36-0.012-
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of STAP1

BRCA0.60-0.080.14proteinmRNASCNVmethylationCCRCC0.070.16-0.02proteinmRNASCNVmethylationCOAD0.19proteinmRNASCNVmethylationGBM-0.02proteinmRNASCNVmethylationHNSCC0.630.020.04proteinmRNASCNVmethylationLSCC0.840.200.19proteinmRNASCNVmethylationLUAD0.66-0.01-0.13proteinmRNASCNVmethylationOV0.16proteinmRNASCNVmethylationPDAC0.60-0.03-0.06proteinmRNASCNVmethylationUCEC0.09proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of STAP1 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.