Gene: STAT4

LinkedOmicsKB © 2022-2023 Zhang Lab

Basic information

Full name
signal transducer and activator of transcription 4
Ensembl
ENSG00000138378.19
Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]
Annotation
Transcription factor

Protein product

Phosphosites on the primary protein product

Tumor and normal comparison

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Signed p-values
Data type
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
RNA-0.022-6.7e-23--1.9e-8-2e-16-1.9e-11--5.4e-5-
protein-0.39-7.8e-7--1.1e-4-4.2e-5-6.5e-7--0.82-0.11

* P-values are from Wilcoxon rank sum test and can be clicked to show the box plots. Positive values mean higher abundance in tumor. BRCA and GBM do not have normal samples.

mRNA expression at gene level
BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC23456789101112log2(RSEM+1)tumornormal
Protein expression
BRCACCRCCGBMHNSCCLSCCLUADPDACUCEC151617181920212223log2(MS1 intensity)tumornormal

* Mild outlier: filled circle; Extreme outlier: empty circle.

Phenotype and mutation association

Manhattan plot summarizing associations of phenotypes and mutations across all cohorts and omics data types

BRCACCRCCCOADGBMHNSCCLSCCLUADOVPDACUCEC051015202530350-5-10-15-20-25-30-35Pan-cancer0204060801001201400-20-40-60-80-100-120-140proteinRNASCNVclinicalpathwaycell typegenomicmutation-log10 of P-value

* Data points of significant associations above and below the dotted lines can be hovered to show the phenotype.

Associations of the protein abundance of STAT4 with phenotypes and mutations

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Signed p-values
Phenotype
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
ESTIMATE: ImmuneScore1.1e-302.2e-160.5-0.0582.2e-52.2e-161.6e-4-7.2e-33.9e-3
HALLMARK_ALLOGRAFT_REJECTION4.8e-302.2e-160.35-0.11.0e-52.2e-163.3e-4-8.7e-39.5e-3
xcell: immune score1.7e-272.2e-160.69-0.153.0e-62.2e-165.5e-6-0.320.023
xcell: T cell CD8+ central memory8.4e-273.2e-120.11-0.731.5e-55.1e-151.9e-7-0.0060.2
xcell: microenvironment score1.9e-251.9e-110.36-0.127.3e-62.2e-169.6e-5-0.355.4e-3
xcell: Myeloid dendritic cell activated6e-256.3e-150.15-0.167.5e-41.2e-151.6e-4-0.110.074
HALLMARK_INTERFERON_GAMMA_RESPONSE1.9e-242.2e-160.75-0.225.1e-52.2e-160.02-0.13.7e-3
HALLMARK_IL6_JAK_STAT3_SIGNALING2.5e-242.2e-16-0.82-0.121.2e-42.2e-160.03-0.0270.005
PROGENy: Trail3.2e-244e-90.018-0.42.3e-32.2e-161.1e-5-0.0090.17
HALLMARK_COMPLEMENT5.3e-241.3e-100.53-0.141.2e-52.2e-160.16-0.0152.7e-4
Showing 1 to 10 of 256 rows

* P-values could be from test for Spearman correlation, Wilcoxon rank sum test, Jonckheere-Terpstra trend test or Cox regression depending on the data type. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Cis-association

Associations between omics data of STAT4

BRCA0.640.210.15proteinmRNASCNVmethylationCCRCC0.420.140.13proteinmRNASCNVmethylationCOAD-0.12proteinmRNASCNVmethylationGBM0.280.15-0.03proteinmRNASCNVmethylationHNSCC0.65-0.07-0.18proteinmRNASCNVmethylationLSCC0.840.080.00proteinmRNASCNVmethylationLUAD0.530.020.08proteinmRNASCNVmethylationOV-0.03proteinmRNASCNVmethylationPDAC0.44-0.070.03proteinmRNASCNVmethylationUCEC0.37-0.110.08proteinmRNASCNVmethylation

* The numbers are Spearman correlation coefficients and can be clicked to show the scatter plots. The color and size of the circles correlate with the coefficients.

Trans-association

Associations of the protein abundance of STAT4 and the protein abundance of other genes

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Signed p-values
Gene
Meta P
BRCA
CCRCC
COAD
GBM
HNSCC
LSCC
LUAD
OV
PDAC
UCEC
No matching records found

* P-values are from test for Spearman correlation. P-values for individual cohorts can be clicked to show the data plots. The matrix icons in each row can be clicked to show a heatmap summary of associations across all cohorts and omics. The rows in the table can be expanded to show results from other omics.

Gene set enrichment analysis

Submit genes and the common logarithm of the p-values of their association with to WebGestalt.